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Bjørndal B, Burri L, Staalesen V, et al. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes. 2011;2011:490650doi: 10.1155/2011/490650.
Bjørndal, B., Burri, L., Staalesen, V., Skorve, J., & Berge, R. K. (2011). Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. Journal of obesity, 2011490650. https://doi.org/10.1155/2011/490650
Bjørndal, Bodil, et al. "Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents." Journal of obesity vol. 2011 (2011): 490650. doi: https://doi.org/10.1155/2011/490650
Bjørndal B, Burri L, Staalesen V, Skorve J, Berge RK. Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes. 2011;2011:490650. doi: 10.1155/2011/490650. Epub 2011 Feb 15. PMID: 21403826; PMCID: PMC3042633.
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J Obes. 2011;2011:490650. doi: 10.1155/2011/490650. Epub 2011 Feb 15.

Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents.

Journal of obesity

Bodil Bjørndal, Lena Burri, Vidar Staalesen, Jon Skorve, Rolf K Berge

Affiliations

  1. Institute of Medicine, University of Bergen, N 5021 Bergen, Norway.

PMID: 21403826 PMCID: PMC3042633 DOI: 10.1155/2011/490650

Abstract

Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots.

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