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Ivers SN, Baranov SA, Sherlock T, et al. Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography. Biomed Opt Express. 2010;1(2):367-377doi: 10.1364/BOE.1.000367.
Ivers, S. N., Baranov, S. A., Sherlock, T., Kourentzi, K., Ruchhoeft, P., Willson, R., & Larin, K. V. (2010). Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography. Biomedical optics express, 1(2), 367-377. https://doi.org/10.1364/BOE.1.000367
Ivers, Steven N, et al. "Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography." Biomedical optics express vol. 1,2 (2010): 367-377. doi: https://doi.org/10.1364/BOE.1.000367
Ivers SN, Baranov SA, Sherlock T, Kourentzi K, Ruchhoeft P, Willson R, Larin KV. Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography. Biomed Opt Express. 2010 Aug 02;1(2):367-377. doi: 10.1364/BOE.1.000367. PMID: 21258473; PMCID: PMC3018009.
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Biomed Opt Express. 2010 Aug 02;1(2):367-377. doi: 10.1364/BOE.1.000367.

Depth-resolved imaging and detection of micro-retroreflectors within biological tissue using Optical Coherence Tomography.

Biomedical optics express

Steven N Ivers, Stephan A Baranov, Tim Sherlock, Katerina Kourentzi, Paul Ruchhoeft, Richard Willson, Kirill V Larin

PMID: 21258473 PMCID: PMC3018009 DOI: 10.1364/BOE.1.000367

Abstract

A new approach to in vivo biosensor design is introduced, based on the use of an implantable micron-sized retroreflector-based platform and non-invasive imaging of its surface reflectivity by Optical Coherence Tomography (OCT). The possibility of using OCT for the depth-resolved imaging and detection of micro-retroreflectors in highly turbid media, including tissue, is demonstrated. The maximum imaging depth for the detection of the micro-retroreflector-based platform within the surrounding media was found to be 0.91 mm for porcine tissue and 1.65 mm for whole milk. With further development, it may be possible to utilize OCT and micro-retroreflectors as a tool for continuous monitoring of analytes in the subcutaneous tissue.

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