Can Fam Physician. 1982 Jul;28:1299-302.
Canadian family physician Medecin de famille canadien
G Feuer, M S Dhami
PMID: 21286123 PMCID: PMC2306441
Drug-induced hepatotoxicity causes 2-5% of hospitalization for jaundice; in the elderly this figure is close to 20%. The liver is particularly susceptible to drug damage because its blood supply delivers drugs in higher concentrations, and because of its role in metabolizing drugs. This article reviews the morphological, biochemical and clinical features of intrahepatic cholestasis, outlining the hypotheses for this frequent side-effect of drug therapy.