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Morimoto M, Numata K, Kondo M, et al. Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib. Hepatol Res. 2011;41(4):296-302doi: 10.1111/j.1872-034X.2011.00778.x.
Morimoto, M., Numata, K., Kondo, M., Hidaka, H., Takada, J., Shibuya, A., Kobayashi, S., Ohkawa, S., Okuse, C., Morita, S., Taguri, M., & Tanaka, K. (2011). Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib. Hepatology research : the official journal of the Japan Society of Hepatology, 41(4), 296-302. https://doi.org/10.1111/j.1872-034X.2011.00778.x
Morimoto, Manabu, et al. "Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib." Hepatology research : the official journal of the Japan Society of Hepatology vol. 41,4 (2011): 296-302. doi: https://doi.org/10.1111/j.1872-034X.2011.00778.x
Morimoto M, Numata K, Kondo M, Hidaka H, Takada J, Shibuya A, Kobayashi S, Ohkawa S, Okuse C, Morita S, Taguri M, Tanaka K. Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib. Hepatol Res. 2011 Apr;41(4):296-302. doi: 10.1111/j.1872-034X.2011.00778.x. Epub 2011 Feb 23. PMID: 21348907.
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Hepatol Res. 2011 Apr;41(4):296-302. doi: 10.1111/j.1872-034X.2011.00778.x. Epub 2011 Feb 23.

Higher discontinuation and lower survival rates are likely in elderly Japanese patients with advanced hepatocellular carcinoma receiving sorafenib.

Hepatology research : the official journal of the Japan Society of Hepatology

Manabu Morimoto, Kazushi Numata, Masaaki Kondo, Hisashi Hidaka, Juichi Takada, Akitaka Shibuya, Satoshi Kobayashi, Shinichi Ohkawa, Chiaki Okuse, Satoshi Morita, Masataka Taguri, Katsuaki Tanaka

Affiliations

  1. Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan. [email protected]

PMID: 21348907 DOI: 10.1111/j.1872-034X.2011.00778.x

Abstract

AIM:   Sorafenib is approved for the treatment of advanced hepatocellular carcinoma (HCC) in Japan; however, its tolerability and efficacy in elderly patients with HCC have not been clarified. We aimed to evaluate the tolerability and efficacy of sorafenib with increasing age.

METHODS:   As part of a retrospective, multicenter cohort study conducted between May 2009 and February 2010, patients with advanced HCC received 400 mg sorafenib twice daily (standard dosage) or once daily (half-dosage) until disease progression or treatment intolerance.

RESULTS:   The mean age of the enrolled patients (n = 76) was 70.3 years, and 24 of them were ≥75 years old. The prognostic factors for survival were age < 75 years, performance status score zero, α-fetoprotein level < 1000 ng/mL, des-gamma-carboxy prothrombin level < 1000 ng/mL, and treatment duration ≥ 1 month. The median treatment duration and overall incidence of adverse drug reactions (ADRs) were not statistically different with increasing age. However, subgroup analysis revealed that treatment discontinuation because of ADRs was more frequent among the ≥75-year-old patients (41.7%) than among the <75-year-old ones (15.0%) with the standard dosage (P = 0.047); this trend was not observed among those who received the half-dose regimen.

CONCLUSIONS:   Sorafenib has modest efficacy and acceptable toxicity in younger (<75 years) patients with HCC; however, elderly patients experience some side effects when it is administered at the standard dosage.

© 2011 The Japan Society of Hepatology.

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