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Redzic Z. Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS. 2011;8(1):3doi: 10.1186/2045-8118-8-3.
Redzic, Z. (2011). Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids and barriers of the CNS, 8(1), 3. https://doi.org/10.1186/2045-8118-8-3
Redzic, Zoran. "Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences." Fluids and barriers of the CNS vol. 8,1 (2011): 3. doi: https://doi.org/10.1186/2045-8118-8-3
Redzic Z. Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS. 2011 Jan 18;8(1):3. doi: 10.1186/2045-8118-8-3. PMID: 21349151; PMCID: PMC3045361.
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Fluids Barriers CNS. 2011 Jan 18;8(1):3. doi: 10.1186/2045-8118-8-3.

Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences.

Fluids and barriers of the CNS

Zoran Redzic

Affiliations

  1. Department of Physiology, Faculty of Medicine, Kuwait University, SAFAT 13110, Kuwait. [email protected].

PMID: 21349151 PMCID: PMC3045361 DOI: 10.1186/2045-8118-8-3

Abstract

Efficient processing of information by the central nervous system (CNS) represents an important evolutionary advantage. Thus, homeostatic mechanisms have developed that provide appropriate circumstances for neuronal signaling, including a highly controlled and stable microenvironment. To provide such a milieu for neurons, extracellular fluids of the CNS are separated from the changeable environment of blood at three major interfaces: at the brain capillaries by the blood-brain barrier (BBB), which is localized at the level of the endothelial cells and separates brain interstitial fluid (ISF) from blood; at the epithelial layer of four choroid plexuses, the blood-cerebrospinal fluid (CSF) barrier (BCSFB), which separates CSF from the CP ISF, and at the arachnoid barrier. The two barriers that represent the largest interface between blood and brain extracellular fluids, the BBB and the BCSFB, prevent the free paracellular diffusion of polar molecules by complex morphological features, including tight junctions (TJs) that interconnect the endothelial and epithelial cells, respectively. The first part of this review focuses on the molecular biology of TJs and adherens junctions in the brain capillary endothelial cells and in the CP epithelial cells. However, normal function of the CNS depends on a constant supply of essential molecules, like glucose and amino acids from the blood, exchange of electrolytes between brain extracellular fluids and blood, as well as on efficient removal of metabolic waste products and excess neurotransmitters from the brain ISF. Therefore, a number of specific transport proteins are expressed in brain capillary endothelial cells and CP epithelial cells that provide transport of nutrients and ions into the CNS and removal of waste products and ions from the CSF. The second part of this review concentrates on the molecular biology of various solute carrier (SLC) transport proteins at those two barriers and underlines differences in their expression between the two barriers. Also, many blood-borne molecules and xenobiotics can diffuse into brain ISF and then into neuronal membranes due to their physicochemical properties. Entry of these compounds could be detrimental for neural transmission and signalling. Thus, BBB and BCSFB express transport proteins that actively restrict entry of lipophilic and amphipathic substances from blood and/or remove those molecules from the brain extracellular fluids. The third part of this review concentrates on the molecular biology of ATP-binding cassette (ABC)-transporters and those SLC transporters that are involved in efflux transport of xenobiotics, their expression at the BBB and BCSFB and differences in expression in the two major blood-brain interfaces. In addition, transport and diffusion of ions by the BBB and CP epithelium are involved in the formation of fluid, the ISF and CSF, respectively, so the last part of this review discusses molecular biology of ion transporters/exchangers and ion channels in the brain endothelial and CP epithelial cells.

References

  1. J Pharmacol Exp Ther. 2002 Jun;301(3):820-9 - PubMed
  2. J Biol Chem. 1995 Jun 23;270(25):14913-8 - PubMed
  3. Mol Pharmacol. 2004 Sep;66(3):413-9 - PubMed
  4. Thromb Res. 2007;120 Suppl 2:S1-6 - PubMed
  5. Pflugers Arch. 2008 Aug;456(5):801-12 - PubMed
  6. Pharmacol Rev. 2005 Jun;57(2):173-85 - PubMed
  7. J Comp Neurol. 2003 Jul 14;462(1):71-89 - PubMed
  8. Brain Res. 1999 Nov 6;846(2):260-4 - PubMed
  9. J Cell Biol. 2001 Aug 6;154(3):491-7 - PubMed
  10. Pharm Res. 2004 Sep;21(9):1680-5 - PubMed
  11. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1607-15 - PubMed
  12. J Cell Physiol. 2004 Mar;198(3):359-69 - PubMed
  13. J Biol Chem. 1999 Jan 29;274(5):3009-16 - PubMed
  14. Brain Res. 1983 Jul 18;271(1):65-71 - PubMed
  15. J Cereb Blood Flow Metab. 2007 May;27(5):909-18 - PubMed
  16. J Neurochem. 2004 Jul;90(2):272-86 - PubMed
  17. Brain Res Dev Brain Res. 1999 Mar 12;113(1-2):47-54 - PubMed
  18. J Cereb Blood Flow Metab. 2009 Sep;29(9):1491-502 - PubMed
  19. J Neurosci. 1990 Dec;10(12):3862-72 - PubMed
  20. J Neurosci. 1996 Feb 1;16(3):877-85 - PubMed
  21. J Neurochem. 1984 Nov;43(5):1369-74 - PubMed
  22. J Cell Mol Med. 2007 May-Jun;11(3):569-79 - PubMed
  23. J Neurochem. 2005 Oct;95(1):294-304 - PubMed
  24. Neurobiol Dis. 2010 Jan;37(1):13-25 - PubMed
  25. Physiol Rev. 2004 Jul;84(3):869-901 - PubMed
  26. Pediatr Res. 2007 Jan;61(1):54-60 - PubMed
  27. J Biol Chem. 1994 Aug 5;269(31):19925-30 - PubMed
  28. Endocrinology. 2008 Dec;149(12):6251-61 - PubMed
  29. J Mol Neurosci. 2011 Jul;44(3):152-8 - PubMed
  30. Am J Physiol Cell Physiol. 2009 Jun;296(6):C1291-300 - PubMed
  31. J Neurochem. 1995 Dec;65(6):2571-6 - PubMed
  32. FASEB J. 2008 Aug;22(8):2723-33 - PubMed
  33. J Biol Chem. 1996 Dec 20;271(51):32916-22 - PubMed
  34. Curr Top Dev Biol. 2008;80:135-70 - PubMed
  35. J Biol Chem. 2000 Oct 6;275(40):30970-6 - PubMed
  36. J Biol Chem. 1988 Oct 25;263(30):15245-8 - PubMed
  37. J Neurochem. 2008 Jan;104(1):113-23 - PubMed
  38. J Neurooncol. 2005 Sep;74(2):113-21 - PubMed
  39. J Cereb Blood Flow Metab. 2002 Mar;22(3):271-9 - PubMed
  40. J Cereb Blood Flow Metab. 2000 Nov;20(11):1557-62 - PubMed
  41. Prog Histochem Cytochem. 1988;18(3):1-99 - PubMed
  42. Prog Brain Res. 2004;146:441-9 - PubMed
  43. Brain Res Dev Brain Res. 1997 Aug 18;102(1):47-52 - PubMed
  44. Brain Res. 2005 Oct 5;1058(1-2):62-72 - PubMed
  45. Mol Biol Cell. 2000 Dec;11(12):4131-42 - PubMed
  46. Biochim Biophys Acta. 2001 Sep 26;1540(3):233-42 - PubMed
  47. J Cell Sci. 1999 Jun;112 ( Pt 12):1879-88 - PubMed
  48. J Comp Neurol. 2008 Oct 10;510(5):497-507 - PubMed
  49. Brain Res. 2010 Oct 28;1358:228-38 - PubMed
  50. J Biol Chem. 1999 Nov 5;274(45):31891-5 - PubMed
  51. Traffic. 2001 Feb;2(2):93-8 - PubMed
  52. J Neurochem. 1989 Nov;53(5):1333-40 - PubMed
  53. Mol Pharmacol. 2002 May;61(5):982-8 - PubMed
  54. Brain Res. 2010 Apr 6;1323:1-10 - PubMed
  55. Pharmacol Biochem Behav. 1984 Dec;21(6):943-6 - PubMed
  56. J Cereb Blood Flow Metab. 2007 Nov;27(11):1766-91 - PubMed
  57. Biochem Genet. 2005 Apr;43(3-4):175-87 - PubMed
  58. J Physiol. 2006 Nov 1;576(Pt 3):769-85 - PubMed
  59. Dev Med Child Neurol. 2007 Sep;49(9):707-16 - PubMed
  60. Int Rev Neurobiol. 2002;51:159-88 - PubMed
  61. Prog Neurobiol. 2009 Apr;87(4):212-51 - PubMed
  62. J Lipid Res. 2001 Jul;42(7):1007-17 - PubMed
  63. Exp Neurol. 2007 Jan;203(1):213-20 - PubMed
  64. Mol Pharmacol. 2008 Jan;73(1):170-7 - PubMed
  65. Biochim Biophys Acta. 1994 Jul 13;1193(1):24-30 - PubMed
  66. J Neurotrauma. 2010 Aug;27(8):1449-61 - PubMed
  67. J Neurochem. 2005 Sep;94(5):1420-6 - PubMed
  68. Microsc Res Tech. 2000 Aug 15;50(4):305-15 - PubMed
  69. Acta Neuropathol. 2010 Jan;119(1):75-88 - PubMed
  70. J Pharm Sci. 2001 Apr;90(4):397-421 - PubMed
  71. Am J Physiol Cell Physiol. 2006 Jul;291(1):C59-67 - PubMed
  72. J Cereb Blood Flow Metab. 2006 Jul;26(7):959-73 - PubMed
  73. J Cereb Blood Flow Metab. 2009 Feb;29(2):411-22 - PubMed
  74. Trends Neurosci. 2001 Dec;24(12):719-25 - PubMed
  75. Psychiatry Res. 2007 Jul 15;155(2):147-54 - PubMed
  76. J Cereb Blood Flow Metab. 2010 Sep;30(9):1625-36 - PubMed
  77. J Neurosci Res. 1989 Apr;22(4):464-72 - PubMed
  78. Adv Drug Deliv Rev. 2005 Apr 25;57(6):883-917 - PubMed
  79. Cell Mol Neurobiol. 2009 Jun;29(4):475-83 - PubMed
  80. Glia. 1995 May;14(1):1-13 - PubMed
  81. Front Neuroenergetics. 2009 Oct 12;1:6 - PubMed
  82. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1197-203 - PubMed
  83. Curr Aging Sci. 2010 Dec;3(3):219-29 - PubMed
  84. Childs Nerv Syst. 1990 Jun;6(4):190-3 - PubMed
  85. Proc Am Thorac Soc. 2004;1(1):38-41 - PubMed
  86. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):223-32 - PubMed
  87. J Cell Sci. 2002 Sep 15;115(Pt 18):3565-73 - PubMed
  88. J Neurosci. 2002 Oct 15;22(20):8922-31 - PubMed
  89. Curr Pharm Des. 2003;9(10):795-800 - PubMed
  90. J Histochem Cytochem. 1999 Oct;47(10):1255-64 - PubMed
  91. Pflugers Arch. 2004 Feb;447(5):619-28 - PubMed
  92. Eur Neuropsychopharmacol. 2008 Mar;18(3):157-69 - PubMed
  93. Endocrinology. 2000 Apr;141(4):1434-41 - PubMed
  94. Expert Opin Drug Metab Toxicol. 2008 Oct;4(10):1245-64 - PubMed
  95. J Biol Chem. 2000 May 26;275(21):16275-80 - PubMed
  96. Pharm Res. 2010 Apr;27(4):673-82 - PubMed
  97. Mol Pharmacol. 2006 Oct;70(4):1212-9 - PubMed
  98. Am J Physiol. 1998 Sep;275(3):E516-24 - PubMed
  99. FASEB J. 2003 Nov;17(14):2085-7 - PubMed
  100. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3900-5 - PubMed
  101. Clin Chem Lab Med. 2002 Dec;40(12):1200-10 - PubMed
  102. FASEB J. 2002 Jun;16(8):860-2 - PubMed
  103. Eur J Cell Biol. 2004 May;83(4):135-44 - PubMed
  104. Cell Transplant. 2000 Jan-Feb;9(1):45-53 - PubMed
  105. Ann Neurol. 2010 Dec;68(6):955-8 - PubMed
  106. Annu Rev Physiol. 2002;64:563-94 - PubMed
  107. Neuropediatrics. 2008 Aug;39(4):211-8 - PubMed
  108. FASEB J. 2004 Oct;18(13):1618-20 - PubMed
  109. J Cereb Blood Flow Metab. 2006 Oct;26(10):1234-49 - PubMed
  110. Biochem J. 1997 Jun 1;324 ( Pt 2):535-41 - PubMed
  111. Drug Metab Dispos. 2003 Nov;31(11):1337-45 - PubMed
  112. Brain Res Dev Brain Res. 1990 Oct 1;56(1):47-53 - PubMed
  113. Brain Res. 2008 Sep 10;1229:18-26 - PubMed
  114. J Pharm Pharmacol. 2001 Apr;53(4):497-503 - PubMed
  115. J Alzheimers Dis. 2004 Aug;6(4):413-20; discussion 443-9 - PubMed
  116. Pharm Res. 2003 May;20(5):720-7 - PubMed
  117. Neuroscience. 2008 Aug 13;155(2):423-38 - PubMed
  118. Neurosci Lett. 2008 Jan 31;431(2):135-40 - PubMed
  119. Neurosci Lett. 2001 Jul 13;307(2):77-80 - PubMed
  120. Neuroscience. 2004;129(2):349-60 - PubMed
  121. Pharm Res. 1995 Oct;12(10):1395-406 - PubMed
  122. Pharmacol Biochem Behav. 1983 Dec;19(6):1037-40 - PubMed
  123. Trends Pharmacol Sci. 2010 Jun;31(6):246-54 - PubMed
  124. Hum Mol Genet. 2006 Apr 1;15(7):1169-79 - PubMed
  125. Am J Physiol. 1994 Dec;267(6 Pt 1):C1616-22 - PubMed
  126. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E10-5 - PubMed
  127. J Gen Physiol. 1981 Apr;77(4):349-71 - PubMed
  128. J Physiol. 1984 May;350:327-42 - PubMed
  129. FASEB J. 2008 Jan;22(1):146-58 - PubMed
  130. J Neurochem. 2010 Jun;113(5):1356-63 - PubMed
  131. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4028-33 - PubMed
  132. Cancer Res. 2005 Dec 15;65(24):11419-28 - PubMed
  133. J Neurochem. 1993 May;60(5):1956-9 - PubMed
  134. Int Rev Cytol. 1974;37(0):349-88 - PubMed
  135. Brain Res. 1992 May 29;581(2):351-5 - PubMed
  136. Expert Opin Drug Deliv. 2006 Nov;3(6):707-12 - PubMed
  137. Neurobiol Aging. 2008 Jun;29(6):902-12 - PubMed
  138. Anat Embryol (Berl). 1980;160(3):263-74 - PubMed
  139. Am J Clin Nutr. 2009 Sep;90(3):867S-874S - PubMed
  140. Annu Rev Physiol. 2010;72:395-412 - PubMed
  141. J Appl Physiol (1985). 2000 Apr;88(4):1474-80 - PubMed
  142. Neuroscience. 2007 Mar 2;145(1):11-9 - PubMed
  143. Neurochem Res. 2009 Mar;34(3):566-73 - PubMed
  144. J Biol Chem. 1993 Apr 15;268(11):8019-25 - PubMed
  145. Am J Physiol. 1997 Mar;272(3 Pt 1):E485-93 - PubMed
  146. Biochem Biophys Res Commun. 2008 Sep 5;373(4):550-4 - PubMed
  147. Neurobiol Aging. 1997 Sep-Oct;18(5):469-74 - PubMed
  148. FASEB J. 1998 Oct;12(13):1319-29 - PubMed
  149. Cerebrospinal Fluid Res. 2008 May 14;5:10 - PubMed
  150. Neuron. 2004 Aug 5;43(3):333-44 - PubMed
  151. J Pharmacol Exp Ther. 2009 Feb;328(2):487-95 - PubMed
  152. J Neurochem. 2010 Dec;115(5):1077-89 - PubMed
  153. J Cell Biol. 1998 Apr 20;141(2):397-408 - PubMed
  154. Neuropathol Appl Neurobiol. 2003 Jun;29(3):211-30 - PubMed
  155. Nat Neurosci. 2001 Mar;4(3):268-74 - PubMed
  156. Pharm Res. 2000 Jan;17(1):55-62 - PubMed
  157. Circ Res. 2010 Mar 19;106(5):842-53 - PubMed
  158. J Cereb Blood Flow Metab. 2010 Nov;30(11):1847-59 - PubMed
  159. J Neurochem. 2008 Dec;107(6):1518-28 - PubMed
  160. Neurobiol Aging. 2008 May;29(5):676-92 - PubMed
  161. Science. 2001 Nov 9;294(5545):1337-40 - PubMed
  162. Am J Physiol. 1990 Jul;259(1 Pt 1):E1-10 - PubMed
  163. J Nutr. 1983 Sep;113(9):1851-60 - PubMed
  164. Physiol Rev. 1983 Oct;63(4):1481-535 - PubMed
  165. Brain Res Mol Brain Res. 1997 Aug;48(1):67-72 - PubMed
  166. Neuroscientist. 2009 Apr;15(2):180-93 - PubMed
  167. J Neurochem. 1987 Nov;49(5):1651-8 - PubMed
  168. Am J Physiol Cell Physiol. 2004 Mar;286(3):C601-10 - PubMed
  169. Biochem J. 2007 Jul 1;405(1):1-9 - PubMed
  170. J Cereb Blood Flow Metab. 1987 Oct;7(5):585-91 - PubMed
  171. J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83 - PubMed
  172. J Pharmacol Exp Ther. 2005 Oct;315(1):240-7 - PubMed
  173. Int J Biochem Cell Biol. 2006 Feb;38(2):222-33 - PubMed
  174. Pharmacol Ther. 2009 Jul;123(1):80-104 - PubMed
  175. Acta Neuropathol. 2009 Jun;117(6):667-75 - PubMed
  176. J Pharmacol Exp Ther. 2001 Nov;299(2):536-41 - PubMed
  177. Neuron. 2010 Sep 9;67(5):834-46 - PubMed
  178. J Cell Biol. 1998 Jul 13;142(1):117-27 - PubMed
  179. J Clin Neurosci. 2010 Jun;17(6):679-84 - PubMed
  180. Science. 1978 Oct 13;202(4364):225-7 - PubMed
  181. J Neurochem. 2004 Aug;90(4):931-41 - PubMed
  182. Am J Pathol. 2007 Apr;170(4):1389-97 - PubMed
  183. J Neurosci. 2009 Apr 29;29(17):5463-75 - PubMed
  184. Mol Biol Cell. 2006 May;17(5):2465-75 - PubMed
  185. Acta Neuropathol. 1989;79(2):117-28 - PubMed
  186. J Neurocytol. 1987 Aug;16(4):433-44 - PubMed
  187. J Chem Neuroanat. 2004 Nov;28(3):117-36 - PubMed
  188. Am J Physiol. 1967 Oct;213(4):1031-8 - PubMed
  189. Am J Physiol. 1990 May;258(5 Pt 2):F1288-94 - PubMed
  190. Exp Brain Res. 2001 Feb;136(4):523-34 - PubMed
  191. Prog Drug Res. 2003;61:39-78 - PubMed
  192. J Med Chem. 1980 Jun;23(6):682-4 - PubMed
  193. Biotechnol Bioeng. 2009 Mar 1;102(4):1251-8 - PubMed
  194. Am J Physiol. 1998 Apr;274(4):C1101-7 - PubMed
  195. J Cell Biol. 2003 May 12;161(3):459-60 - PubMed
  196. Brain Res. 2000 Jan 31;854(1-2):197-206 - PubMed
  197. Cerebrospinal Fluid Res. 2006 Mar 29;3:4 - PubMed
  198. Acta Neurochir Suppl. 2006;96:451-6 - PubMed
  199. J Bioenerg Biomembr. 2001 Dec;33(6):481-91 - PubMed
  200. Biopolymers. 2008;90(5):589-94 - PubMed
  201. J Cereb Blood Flow Metab. 2009 Jun;29(6):1084-98 - PubMed
  202. J Mol Biol. 2005 Sep 9;352(1):151-64 - PubMed
  203. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):311-6 - PubMed
  204. Brain Res. 1978 Mar 17;143(1):27-41 - PubMed
  205. J Biol Chem. 1993 Apr 25;268(12):8514-20 - PubMed
  206. Physiology (Bethesda). 2010 Aug;25(4):239-49 - PubMed
  207. Eur J Pharmacol. 1998 Apr 24;347(2-3):205-9 - PubMed
  208. J Neurochem. 2007 Oct;103(2):425-38 - PubMed
  209. Neurochem Int. 2004 Sep;45(4):545-52 - PubMed
  210. Biochim Biophys Acta. 1990 Jun 27;1025(2):191-8 - PubMed
  211. J Neural Transm (Vienna). 2011 Jan;118(1):115-33 - PubMed
  212. Mol Pharmacol. 2007 Mar;71(3):667-75 - PubMed
  213. Ann N Y Acad Sci. 1986;481:123-34 - PubMed
  214. Pharm Res. 2007 Jul;24(7):1227-51 - PubMed
  215. Pharm Res. 2006 Feb;23(2):291-302 - PubMed
  216. Mol Pharmacol. 2006 Feb;69(2):462-70 - PubMed
  217. J Pharmacol Sci. 2003 Dec;93(4):430-6 - PubMed
  218. Science. 1985 Sep 6;229(4717):941-5 - PubMed
  219. J Neuropathol Exp Neurol. 1998 May;57(5):404-14 - PubMed
  220. J Neurosci. 2005 Dec 14;25(50):11495-503 - PubMed
  221. J Cell Biol. 2003 May 12;161(3):653-60 - PubMed
  222. Best Pract Res Clin Endocrinol Metab. 2007 Jun;21(2):307-21 - PubMed
  223. J Neurochem. 1987 Jul;49(1):310-5 - PubMed
  224. Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1485-94 - PubMed
  225. Exp Neurol. 1996 Nov;142(1):47-65 - PubMed
  226. Annu Rev Nutr. 1996;16:235-56 - PubMed
  227. Adv Drug Deliv Rev. 2004 Oct 14;56(12):1717-40 - PubMed
  228. Biochem Biophys Res Commun. 2007 Sep 21;361(2):301-6 - PubMed
  229. Am J Physiol. 1993 Apr;264(4 Pt 1):C761-82 - PubMed
  230. J Biol Chem. 1997 Apr 11;272(15):10205-11 - PubMed
  231. Prog Biophys Mol Biol. 2003 Jan;81(1):1-44 - PubMed
  232. Neurotoxicology. 2010 Sep;31(5):524-32 - PubMed
  233. J Neurochem. 1993 Mar;60(3):793-803 - PubMed
  234. Anat Embryol (Berl). 1999 May;199(5):439-49 - PubMed
  235. Xenobiotica. 2008 Jul;38(7-8):1022-42 - PubMed
  236. Pflugers Arch. 2003 Feb;445(5):529-33 - PubMed
  237. Pharmacogenetics. 2002 Oct;12(7):535-41 - PubMed
  238. CNS Neurol Disord Drug Targets. 2009 Mar;8(1):16-30 - PubMed
  239. Brain Dev. 2009 Aug;31(7):545-52 - PubMed
  240. Nat Med. 2007 Sep;13(9):1029-31 - PubMed
  241. Brain Res. 2000 Mar 24;859(2):286-92 - PubMed
  242. Am J Physiol. 1999 Jan;276(1):C82-90 - PubMed
  243. J Physiol. 1985 May;362:245-60 - PubMed
  244. J Pharm Sci. 2004 Jan;93(1):99-107 - PubMed
  245. Adv Drug Deliv Rev. 2003 Jan 21;55(1):3-29 - PubMed
  246. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a002899 - PubMed
  247. Cerebrovasc Brain Metab Rev. 1992 Fall;4(3):261-86 - PubMed
  248. FASEB J. 1994 Oct;8(13):1003-11 - PubMed
  249. Neuroendocrinology. 2006;84(5):339-45 - PubMed
  250. J Cereb Blood Flow Metab. 2003 Nov;23(11):1282-6 - PubMed
  251. J Nutr. 2006 Jan;136(1 Suppl):218S-26S - PubMed

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