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Kuranov RV, Qiu J, McElroy AB, et al. Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography. Biomed Opt Express. 2011;2(3):491-504doi: 10.1364/BOE.2.000491.
Kuranov, R. V., Qiu, J., McElroy, A. B., Estrada, A., Salvaggio, A., Kiel, J., Dunn, A. K., Duong, T. Q., & Milner, T. E. (2011). Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography. Biomedical optics express, 2(3), 491-504. https://doi.org/10.1364/BOE.2.000491
Kuranov, Roman V, et al. "Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography." Biomedical optics express vol. 2,3 (2011): 491-504. doi: https://doi.org/10.1364/BOE.2.000491
Kuranov RV, Qiu J, McElroy AB, Estrada A, Salvaggio A, Kiel J, Dunn AK, Duong TQ, Milner TE. Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography. Biomed Opt Express. 2011 Feb 03;2(3):491-504. doi: 10.1364/BOE.2.000491. PMID: 21412455; PMCID: PMC3047355.
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Biomed Opt Express. 2011 Feb 03;2(3):491-504. doi: 10.1364/BOE.2.000491.

Depth-resolved blood oxygen saturation measurement by dual-wavelength photothermal (DWP) optical coherence tomography.

Biomedical optics express

Roman V Kuranov, Jinze Qiu, Austin B McElroy, Arnold Estrada, Anthony Salvaggio, Jeffrey Kiel, Andrew K Dunn, Timothy Q Duong, Thomas E Milner

PMID: 21412455 PMCID: PMC3047355 DOI: 10.1364/BOE.2.000491

Abstract

Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel phantom. DWP OCT SaO(2) is linearly correlated with blood-gas SaO(2) measurements. We demonstrate 6.3% precision in SaO(2) levels measured a phantom blood vessel using DWP-OCT with 800 and 765 nm excitation wavelengths. Sources of uncertainty in SaO(2) levels measured with DWP-OCT are identified and characterized.

Keywords: (120.5050) Phase measurement; (170.1470) Blood or tissue constituent monitoring; (170.4500) Optical Coherence Tomography; (170.6510) Spectroscopy, tissue diagnostics; (300.1030) Absorption

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