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Chen J, Huang XF. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol. 2009;3(3):154-8doi: 10.1016/j.jacl.2009.04.054.
Chen, J., & Huang, X. F. (2009). The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. Journal of clinical lipidology, 3(3), 154-8. https://doi.org/10.1016/j.jacl.2009.04.054
Chen, Jiezhong, and Huang, Xu-Feng. "The effects of diets enriched in beta-glucans on blood lipoprotein concentrations." Journal of clinical lipidology vol. 3,3 (2009): 154-8. doi: https://doi.org/10.1016/j.jacl.2009.04.054
Chen J, Huang XF. The effects of diets enriched in beta-glucans on blood lipoprotein concentrations. J Clin Lipidol. 2009 May-Jun;3(3):154-8. doi: 10.1016/j.jacl.2009.04.054. Epub 2009 May 05. PMID: 21291810.
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J Clin Lipidol. 2009 May-Jun;3(3):154-8. doi: 10.1016/j.jacl.2009.04.054. Epub 2009 May 05.

The effects of diets enriched in beta-glucans on blood lipoprotein concentrations.

Journal of clinical lipidology

Jiezhong Chen, Xu-Feng Huang

Affiliations

  1. School of Health Sciences, University of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia.

PMID: 21291810 DOI: 10.1016/j.jacl.2009.04.054

Abstract

Dietary beta-glucans lower the blood concentrations of cholesterol in animals and humans. Recent studies have uncovered mechanisms by which dietary beta-glucans may regulate cholesterol homeostasis. There is evidence that beta-glucans sequester bile acids in the intestine, reducing their reabsorption and return to the liver. Reducing hepatic bile acid concentrations activates the enzyme CYP7A1, which converts cholesterol into bile acids. This action leads to a reduction of hepatic cell cholesterol content, which up-regulates low-density lipoprotein (LDL) receptor synthesis and thereby accelerates the transportation of LDL-cholesterol from the blood into hepatocytes. Reduced intracellular cholesterol also up-regulates the hepatic synthesis of 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase and could therefore provide an additive effect in suppressing hepatocyte cholesterol to that produced by enhancing its depletion with beta-glucans. Through this combination of agents, one would expect a greater clearance of LDL from the plasma with lower steady state levels of LDL-cholesterol.

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