Display options
Cite
Dixit VD, Yang H, Sayeed KS, et al. Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J Inflamm (Lond). 2011;8:6doi: 10.1186/1476-9255-8-6.
Dixit, V. D., Yang, H., Sayeed, K. S., Stote, K. S., Rumpler, W. V., Baer, D. J., Longo, D. L., Mattson, M. P., & Taub, D. D. (2011). Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. Journal of inflammation (London, England), 86. https://doi.org/10.1186/1476-9255-8-6
Dixit, Vishwa Deep, et al. "Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production." Journal of inflammation (London, England) vol. 8 (2011): 6. doi: https://doi.org/10.1186/1476-9255-8-6
Dixit VD, Yang H, Sayeed KS, Stote KS, Rumpler WV, Baer DJ, Longo DL, Mattson MP, Taub DD. Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J Inflamm (Lond). 2011 Mar 07;8:6. doi: 10.1186/1476-9255-8-6. PMID: 21385360; PMCID: PMC3058015.
Copy Download .nbib Format: NLM
Share it on

J Inflamm (Lond). 2011 Mar 07;8:6. doi: 10.1186/1476-9255-8-6.

Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production.

Journal of inflammation (London, England)

Vishwa Deep Dixit, Hyunwon Yang, Khaleel S Sayeed, Kim S Stote, William V Rumpler, David J Baer, Dan L Longo, Mark P Mattson, Dennis D Taub

Affiliations

  1. Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, (251 Bayview Boulevard), Baltimore, MD, (21224), USA. [email protected].

PMID: 21385360 PMCID: PMC3058015 DOI: 10.1186/1476-9255-8-6

Abstract

BACKGROUND: Intermittent fasting (IF) improves healthy lifespan in animals by a mechanism involving reduced oxidative damage and increased resistance to stress. However, no studies have evaluated the impact of controlled meal frequency on immune responses in human subjects.

OBJECTIVE: A study was conducted to establish the effects of controlled diets with different meal frequencies, but similar daily energy intakes, on cytokine production in healthy male and female subjects.

DESIGN: In a crossover study design with an intervening washout period, healthy normal weight middle-age male and female subjects (n = 15) were maintained for 2 months on controlled on-site one meal per day (OMD) or three meals per day (TMD) isocaloric diets. Serum samples and peripheral blood mononuclear cells (PBMCs) culture supernatants from subjects were analyzed for the presence of inflammatory markers using a multiplex assay.

RESULTS: There were no significant differences in the inflammatory markers in the serum of subjects on the OMD or TMD diets. There was an increase in the capacity of PBMCs to produce cytokines in subjects during the first month on the OMD or TMD diets.Lower levels of TNF-α, IL-17, MCP-1 and MIP-1β were produced by PBMCs from subjects on the OMD versus TMD diet.

CONCLUSIONS: PBMCs of subjects on controlled diets exhibit hypersensitivities to cellular stimulation suggesting that stress associated with altered eating behavior might affect cytokine production by immune cells upon stimulation. Moreover, stimulated PBMCs derived from healthy individuals on a reduced meal frequency diet respond with a reduced capability to produce cytokines.

References

  1. Circulation. 2005 Nov 15;112(20):3115-21 - PubMed
  2. J Neurosci Res. 1999 Sep 15;57(6):830-9 - PubMed
  3. Circulation. 2007 Feb 27;115(8):972-80 - PubMed
  4. J Immunol. 2007 Feb 1;178(3):1748-58 - PubMed
  5. J Neurosci Res. 1999 Jul 15;57(2):195-206 - PubMed
  6. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1920-5 - PubMed
  7. Mech Ageing Dev. 1997 Feb;93(1-3):87-94 - PubMed
  8. Exp Gerontol. 1992 Sep-Dec;27(5-6):575-81 - PubMed
  9. FASEB J. 2006 Apr;20(6):631-7 - PubMed
  10. Nature. 2007 Feb 8;445(7128):648-51 - PubMed
  11. Brain Behav Immun. 2004 May;18(3):231-7 - PubMed
  12. Ageing Res Rev. 2006 Aug;5(3):332-53 - PubMed
  13. J Gerontol. 1986 Jan;41(1):13-9 - PubMed
  14. Nat Immunol. 2005 Nov;6(11):1123-32 - PubMed
  15. Am J Med Sci. 2006 Apr;331(4):166-74 - PubMed
  16. Neurobiol Dis. 2007 Apr;26(1):212-20 - PubMed
  17. Metabolism. 2007 Dec;56(12):1729-34 - PubMed
  18. Nat Immunol. 2005 Nov;6(11):1133-41 - PubMed
  19. Nature. 2006 Dec 14;444(7121):875-80 - PubMed
  20. Psychosom Med. 2003 Jul-Aug;65(4):598-603 - PubMed
  21. Circulation. 2005 Aug 16;112(7):976-83 - PubMed
  22. J Am Coll Nutr. 2003 Apr;22(2):174-82 - PubMed
  23. J Clin Invest. 2003 Jan;111(2):241-50 - PubMed
  24. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10630-5 - PubMed
  25. Immunity. 2006 Jun;24(6):677-688 - PubMed
  26. J Clin Invest. 2004 Jul;114(1):57-66 - PubMed
  27. Am J Clin Nutr. 2007 Apr;85(4):981-8 - PubMed
  28. Mech Ageing Dev. 1997 Feb;93(1-3):25-33 - PubMed
  29. Am J Respir Cell Mol Biol. 1998 Sep;19(3):462-9 - PubMed
  30. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5150-5 - PubMed
  31. Nature. 2003 Mar 6;422(6927):27-8 - PubMed
  32. Clin Diagn Lab Immunol. 2002 Jan;9(1):182-3 - PubMed
  33. Exp Gerontol. 2005 Nov;40(11):884-93 - PubMed
  34. Free Radic Biol Med. 2007 Mar 1;42(5):665-74 - PubMed
  35. J Gerontol. 1983 Jan;38(1):36-45 - PubMed
  36. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6216-20 - PubMed
  37. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6659-63 - PubMed
  38. Annu Rev Med. 2003;54:131-52 - PubMed
  39. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53 - PubMed
  40. Science. 2005 Jan 21;307(5708):426-30 - PubMed
  41. Trends Immunol. 2004 Apr;25(4):193-200 - PubMed
  42. Lancet. 2005 Jun 4-10;365(9475):1978-80 - PubMed
  43. JAMA. 2006 Apr 5;295(13):1539-48 - PubMed
  44. Exp Gerontol. 2005 Nov;40(11):900-10 - PubMed
  45. Prog Clin Biol Res. 1981;67:319-25 - PubMed

Publication Types