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Ruiz-Delgado GJ, López-Otero A, Hernandez-Arizpe A, et al. Poor hematopoietic stem cell mobilizers in multiple myeloma: a single institution experience. Mediterr J Hematol Infect Dis. 2010;2(2):e2010016doi: 10.4084/MJHID.2010.016.
Ruiz-Delgado, G. J., López-Otero, A., Hernandez-Arizpe, A., Ramirez-Medina, A., & Ruiz-Argüelles, G. J. (2010). Poor hematopoietic stem cell mobilizers in multiple myeloma: a single institution experience. Mediterranean journal of hematology and infectious diseases, 2(2), e2010016. https://doi.org/10.4084/MJHID.2010.016
Ruiz-Delgado, Guillermo J, et al. "Poor hematopoietic stem cell mobilizers in multiple myeloma: a single institution experience." Mediterranean journal of hematology and infectious diseases vol. 2,2 (2010): e2010016. doi: https://doi.org/10.4084/MJHID.2010.016
Ruiz-Delgado GJ, López-Otero A, Hernandez-Arizpe A, Ramirez-Medina A, Ruiz-Argüelles GJ. Poor hematopoietic stem cell mobilizers in multiple myeloma: a single institution experience. Mediterr J Hematol Infect Dis. 2010 Jun 21;2(2):e2010016. doi: 10.4084/MJHID.2010.016. PMID: 21415967; PMCID: PMC3033130.
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Mediterr J Hematol Infect Dis. 2010 Jun 21;2(2):e2010016. doi: 10.4084/MJHID.2010.016.

Poor hematopoietic stem cell mobilizers in multiple myeloma: a single institution experience.

Mediterranean journal of hematology and infectious diseases

Guillermo J Ruiz-Delgado, Avril López-Otero, Ana Hernandez-Arizpe, Aura Ramirez-Medina, Guillermo J Ruiz-Argüelles

Affiliations

  1. Centro de Hematología y Medicina Interna de Puebla. Puebla, MEXICO.

PMID: 21415967 PMCID: PMC3033130 DOI: 10.4084/MJHID.2010.016

Abstract

In a single institution, in a group of 28 myeloma patients deemed eligible for autologous transplant, stem cell mobilization was attempted using filgrastim: 26 individuals were given 31 autografts employing 1-4 (median three) apheresis sessions, to obtain a target stem cell dose of 1 x 10(6) CD34 +ve viable cells / Kg of the recipient. The median number of grafted CD34 cells was 7.56 x 10(6) / Kg of the recipient; the range being 0.92 to 14.8. By defining as poor mobilizers individuals in which a cell collection of < 1 x 10(6) CD34 viable cells / Kg was obtained, a subset of eight poor mobilizers was identified; in two patients the autograft was aborted because of an extremely poor CD34 +ve cell yield (< 0.2 x 10(6) CD34 +ve viable cells / Kg of the recipient) after four apheresis sessions. The long-term overall survival of the patients grafted with > 1 x 10(6) CD34 +ve viable cells / Kg was better (80% at 80 months) than those grafted with < 1 x 10(6) CD34 +ve viable cells / Kg (67% at 76 months). Methods to improve stem cell mobilization are needed and may result in obtaining better results when autografting multiple myeloma patients.

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