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Choi JM, Kim HH, Park SJ, et al. Development of pseudomembranous colitis four months after initiation of rifampicin. Case Rep Gastroenterol. 2011;5(1):45-51doi: 10.1159/000323753.
Choi, J. M., Kim, H. H., Park, S. J., Park, M. I., & Moon, W. (2011). Development of pseudomembranous colitis four months after initiation of rifampicin. Case reports in gastroenterology, 5(1), 45-51. https://doi.org/10.1159/000323753
Choi, Jeong Moon, et al. "Development of pseudomembranous colitis four months after initiation of rifampicin." Case reports in gastroenterology vol. 5,1 (2011): 45-51. doi: https://doi.org/10.1159/000323753
Choi JM, Kim HH, Park SJ, Park MI, Moon W. Development of pseudomembranous colitis four months after initiation of rifampicin. Case Rep Gastroenterol. 2011 Jan 14;5(1):45-51. doi: 10.1159/000323753. PMID: 21326858; PMCID: PMC3037994.
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Case Rep Gastroenterol. 2011 Jan 14;5(1):45-51. doi: 10.1159/000323753.

Development of pseudomembranous colitis four months after initiation of rifampicin.

Case reports in gastroenterology

Jeong Moon Choi, Hyung Hun Kim, Seun Ja Park, Moo In Park, Won Moon

Affiliations

  1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

PMID: 21326858 PMCID: PMC3037994 DOI: 10.1159/000323753

Abstract

Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary tuberculosis and started on a standard HERZ regimen (isoniazid, ethambutol, rifampicin, pyrazinamide). After 4 months of HERZ, he presented with frequent bloody, mucoid, jelly-like diarrhea and lower abdominal pain. Sigmoidoscopy revealed multiple whitish plaques with edematous mucosa that were compatible with PMC. Biopsies from these lesions showed ulcer-related necrotic and granulation tissue. We stopped antitubercular treatment and started the patient on oral metronidazole. His symptoms completely resolved within 2 weeks. Antitubercular treatment was restarted by replacing rifampicin with levofloxacin. The patient did not present with diarrhea or bloody stool throughout the rest of treatment.

Keywords: Pseudomembranous colitis; Rifampicin; Tuberculosis

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