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Ohno Y, Hirai K, Nakanishi M, et al. Serum protein and immunoglobulin levels among nepalese living in southern Nepal. Environ Health Prev Med. 2002;7(3):119-22doi: 10.1265/ehpm.2002.119.
Ohno, Y., Hirai, K., Nakanishi, M., Nagata, K., Tamura, T., & Shrestha, M. P. (2002). Serum protein and immunoglobulin levels among nepalese living in southern Nepal. Environmental health and preventive medicine, 7(3), 119-22. https://doi.org/10.1265/ehpm.2002.119
Ohno, Yoshimi, et al. "Serum protein and immunoglobulin levels among nepalese living in southern Nepal." Environmental health and preventive medicine vol. 7,3 (2002): 119-22. doi: https://doi.org/10.1265/ehpm.2002.119
Ohno Y, Hirai K, Nakanishi M, Nagata K, Tamura T, Shrestha MP. Serum protein and immunoglobulin levels among nepalese living in southern Nepal. Environ Health Prev Med. 2002 Jul;7(3):119-22. doi: 10.1265/ehpm.2002.119. PMID: 21432293; PMCID: PMC2723493.
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Environ Health Prev Med. 2002 Jul;7(3):119-22. doi: 10.1265/ehpm.2002.119.

Serum protein and immunoglobulin levels among nepalese living in southern Nepal.

Environmental health and preventive medicine

Yoshimi Ohno, Kazuko Hirai, Mamoru Nakanishi, Kumiko Nagata, Toshihide Tamura, Mathura P Shrestha

Affiliations

  1. Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, 6-46, Ikebiraki-cho, 663-8558, Nishinomiya, Hyogo, Japan.

PMID: 21432293 PMCID: PMC2723493 DOI: 10.1265/ehpm.2002.119

Abstract

OBJECTIVE: This study examined the levels of serum protein fractionation, immunoglobulin (Ig) and antistreptolysin O (ASO) of people (91 males and 84 females aged 10-68 years) living in the Terai region of southern Nepal, as there has previously been no information available about them.

METHODS: Blood samples were collected early in the morning after overnight fasting. Serum protein fractionation was carried out by cellulose-acetate electrophoresis. IgG, IgA, IgM and ASO were measured by immuno-turbidimetry with clinical kits.

RESULTS: The mean proportion of albumin (Alb) was rather low due to increased globulin (Glb). The Alb level of males was significantly higher than that of females, while the male γ-Glb level was significantly lower than that of females. The mean values of IgG, IgM and ASO for males were lower than those values for females, although the difference was significant only for the IgM value. The mean values of IgM for female age groups of 30-39 years or less were significantly higher than those for the corresponding male age groups. Age correlated positively with IgA, and negatively with ASO in both sexes. γ-Glb and IgG correlated significantly with TP, AlB, α(1)-Glb and IgA in both sexes. ASO correlated with β-Glb and IgA in males, and with γ-Glb and IgG in females.

CONCLUSIONS: The fact that the level of γ-Glb, a major component of serum globulin, was high suggested exposure to a highly bacterial and viral environment. These results point to the need to prevent infectious diseases as well as improve their nutritional status, especially for children and young adults.

Keywords: Nepalese; antistreptolysin O; immunoglobulin; protein fractionation; serum protein

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