Environ Health Prev Med. 1998 Oct;3(3):123-9. doi: 10.1007/BF02931702.
Sex steroids, bone turnover and bone mineral density in pre-, peri-, and postmenopausal women.
Environmental health and preventive medicine
T Akatsu
Affiliations
Affiliations
- Department of Preventive Medicine and Public Health School of Medicine, Keio University, 35 Shinanomachi, Shinjyuku, 160-8582, Tokyo, Japan.
PMID: 21432491
PMCID: PMC2723360 DOI: 10.1007/BF02931702
Abstract
To examine 1) the relationships between endogenous androgens and bone mineral density (BMD), 2) the relationships between sex-hormone binding globulin (SHBG) and BMD, and 3) the associations of endogenous androgens and SHBG with biochemical markers of bone turnover, a cross-sectional study was carried out in 88 healthy pre-, peri-, and postmenopausal women aged 35 to 74. Measurements of BMD(s) at the ultradistal radius and ulna, and the distal radius (using DEXA), estrogens, androgens, deoxypyridinoline (D-Pyr) and intact bone gla protein (I-BGP) were performed. In the multivariate regression models testosterone (T) was positively correlated with BMD at the ultradistal radius and ulna in perimenopausal women, and was positively correlated with BMD at the ultradistal radius and ulna, and the distal radius in postmenopausal women. T was positively associated with I-BGP in premenopausal women (r = 0.65, p < 0.01), and negatively associated with D-Pyr in pre- (r = -0.53, p < 0.05) and postmenopausal women (r = -0.49, p < 0.001). On the other hand, SHBG was negatively correlated with BMD at die ultradistal radius and ulna, and die distal radius in pre- and postmenopausal women in the models. SHBG was positively related to D-Pyr in pre(r = 0.57, p < 0.05) and postmenopausal women (r = 0.41, p < 0.01), and negatively related to I-BGP in postmenopausal women (r = -0.38, p < 0.01). These findings suggest that endogenous androgens may exert positive influences on BMD, and that SHBG may have negative effects on BMD.
Keywords: androgens; biochemical marker of bone turnover; bone mineral density; estrogens; sex-hormone binding globulin
References
- Calcif Tissue Int. 1987 Feb;40(2):59-63 - PubMed
- J Clin Invest. 1988 Jun;81(6):1804-9 - PubMed
- Br Med J (Clin Res Ed). 1986 Apr 26;292(6528):1098-100 - PubMed
- Br Med J. 1977 Nov 5;2(6096):1177-9 - PubMed
- N Engl J Med. 1993 Oct 14;329(16):1141-6 - PubMed
- J Clin Endocrinol Metab. 1988 Nov;67(5):937-43 - PubMed
- N Engl J Med. 1985 Oct 17;313(16):973-5 - PubMed
- Lancet. 1993 Jan 9;341(8837):72-5 - PubMed
- Arch Intern Med. 1988 Jan;148(1):121-3 - PubMed
- J Bone Miner Res. 1995 Jan;10(1):26-35 - PubMed
- J Bone Miner Res. 1991 Apr;6(4):331-8 - PubMed
- J Clin Endocrinol Metab. 1989 Sep;69(3):533-9 - PubMed
- Osteoporos Int. 1991 Sep;1(4):218-31 - PubMed
- Obstet Gynecol. 1983 Mar;61(3):275-8 - PubMed
- N Engl J Med. 1988 Mar 31;318(13):818-28 - PubMed
- J Clin Invest. 1996 Jan 1;97(1):14-21 - PubMed
- N Engl J Med. 1992 Jul 9;327(2):82-7 - PubMed
- J Chromatogr. 1990 Jan 26;525(1):43-57 - PubMed
- N Engl J Med. 1985 Aug 15;313(7):453 - PubMed
- J Clin Invest. 1992 Dec;90(6):2464-71 - PubMed
- Clin Chem. 1992 Nov;38(11):2233-8 - PubMed
- J Bone Miner Res. 1995 Aug;10(8):1177-84 - PubMed
- Clin Endocrinol (Oxf). 1989 Oct;31(4):499-509 - PubMed
- Calcif Tissue Res. 1976 Apr 13;20(1):41-52 - PubMed
- JAMA. 1990 Jan 26;263(4):545-8 - PubMed
- J Clin Endocrinol Metab. 1985 Apr;60(4):651-7 - PubMed
- J Clin Endocrinol Metab. 1995 Apr;80(4):1118-23 - PubMed
- J Clin Endocrinol Metab. 1982 Jan;54(1):115-20 - PubMed
- JAMA. 1992 Nov 4;268(17):2403-8 - PubMed
- J Clin Endocrinol Metab. 1992 Jan;74(1):20-3 - PubMed
- J Clin Endocrinol Metab. 1988 Jun;66(6):1247-50 - PubMed
- Semin Arthritis Rheum. 1990 Jun;19(6):371-6 - PubMed
- N Engl J Med. 1987 Nov 5;317(19):1169-74 - PubMed
- Ann Clin Biochem. 1990 Nov;27 ( Pt 6):532-41 - PubMed
- Lancet. 1979 Sep 22;2(8143):597-600 - PubMed
- J Clin Invest. 1986 Sep;78(3):618-21 - PubMed
- Clin Invest Med. 1982;5(2-3):163-7 - PubMed
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