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Belayev L, Khoutorova L, Atkins KD, et al. Docosahexaenoic Acid therapy of experimental ischemic stroke. Transl Stroke Res. 2010;2(1):33-41doi: 10.1007/s12975-010-0046-0.
Belayev, L., Khoutorova, L., Atkins, K. D., Eady, T. N., Hong, S., Lu, Y., Obenaus, A., & Bazan, N. G. (2011). Docosahexaenoic Acid therapy of experimental ischemic stroke. Translational stroke research, 2(1), 33-41. https://doi.org/10.1007/s12975-010-0046-0
Belayev, Ludmila, et al. "Docosahexaenoic Acid therapy of experimental ischemic stroke." Translational stroke research vol. 2,1 (2011): 33-41. doi: https://doi.org/10.1007/s12975-010-0046-0
Belayev L, Khoutorova L, Atkins KD, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG. Docosahexaenoic Acid therapy of experimental ischemic stroke. Transl Stroke Res. 2011 Mar;2(1):33-41. doi: 10.1007/s12975-010-0046-0. Epub 2010 Nov 04. PMID: 21423332; PMCID: PMC3037476.
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Transl Stroke Res. 2011 Mar;2(1):33-41. doi: 10.1007/s12975-010-0046-0. Epub 2010 Nov 04.

Docosahexaenoic Acid therapy of experimental ischemic stroke.

Translational stroke research

Ludmila Belayev, Larissa Khoutorova, Kristal D Atkins, Tiffany N Eady, Song Hong, Yan Lu, Andre Obenaus, Nicolas G Bazan

PMID: 21423332 PMCID: PMC3037476 DOI: 10.1007/s12975-010-0046-0

Abstract

We examined the neuroprotective efficacy of docosahexaenoic acid (DHA), an omega-3 essential fatty acid family member, in acute ischemic stroke; studied the therapeutic window; and investigated whether DHA administration after an ischemic stroke is able to salvage the penumbra. In each series described below, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo). In series 1, DHA or saline was administered i.v. at 3, 4, 5, or 6 h after stroke. In series 2, MRI was conducted on days 1, 3 and 7. In series 3, DHA or saline was administered at 3 h, and lipidomic analysis was conducted on day 3. Treatment with DHA significantly improved behavior and reduced total infarct volume by a mean of 40% when administered at 3 h, by 66% at 4 h, and by 59% at 5 h. Total lesion volumes computed from T2-weighted images were reduced in the DHA group at all time points. Lipidomic analysis showed that DHA treatment potentiates neuroprotectin D1 (NPD1) synthesis in the penumbra 3 days after MCAo. DHA administration provides neurobehavioral recovery, reduces brain infarction and edema, and activates NPD1 synthesis in the penumbra when administered up to 5 h after focal cerebral ischemia in rats.

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