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Newland JG, Abdel-Rahman SM. Update on terbinafine with a focus on dermatophytoses. Clin Cosmet Investig Dermatol. 2009;2:49-63doi: 10.2147/ccid.s3690.
Newland, J. G., & Abdel-Rahman, S. M. (2009). Update on terbinafine with a focus on dermatophytoses. Clinical, cosmetic and investigational dermatology, 249-63. https://doi.org/10.2147/ccid.s3690
Newland, Jason G, and Abdel-Rahman, Susan M. "Update on terbinafine with a focus on dermatophytoses." Clinical, cosmetic and investigational dermatology vol. 2 (2009): 49-63. doi: https://doi.org/10.2147/ccid.s3690
Newland JG, Abdel-Rahman SM. Update on terbinafine with a focus on dermatophytoses. Clin Cosmet Investig Dermatol. 2009 Apr 21;2:49-63. doi: 10.2147/ccid.s3690. PMID: 21436968; PMCID: PMC3047923.
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Clin Cosmet Investig Dermatol. 2009 Apr 21;2:49-63. doi: 10.2147/ccid.s3690.

Update on terbinafine with a focus on dermatophytoses.

Clinical, cosmetic and investigational dermatology

Jason G Newland, Susan M Abdel-Rahman

Affiliations

  1. Division of Infectious Diseases, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

PMID: 21436968 PMCID: PMC3047923 DOI: 10.2147/ccid.s3690

Abstract

Since terbinafine was introduced on the world market 17 years ago, it has become the leading antifungal for the treatment of superficial fungal infections, aided by unique pharmacologic and microbiologic profiles. This article reviews mode of action, antimycotic spectrum and disposition profile of terbinafine. It examines the data, accumulated over 15 years, on the comparative efficacy of terbinafine (vs griseofulvin, itraconazole, fluconazole) in the management of the infections for which it is primarily indicated (eg, dermatophytoses) and provides a brief discussion on its use for the treatment of non-dermatophyte infections. Finally, the available data on the newest topical and systemic formulations are introduced.

Keywords: Microsporum; Trichophyton; allylamine; antifungal; tinea

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