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Lapolla A, Dalfrà MG, Fedele D. Management of gestational diabetes mellitus. Diabetes Metab Syndr Obes. 2009;2:73-82doi: 10.2147/dmsott.s3407.
Lapolla, A., Dalfrà, M. G., & Fedele, D. (2009). Management of gestational diabetes mellitus. Diabetes, metabolic syndrome and obesity : targets and therapy, 273-82. https://doi.org/10.2147/dmsott.s3407
Lapolla, Annunziata, et al. "Management of gestational diabetes mellitus." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 2 (2009): 73-82. doi: https://doi.org/10.2147/dmsott.s3407
Lapolla A, Dalfrà MG, Fedele D. Management of gestational diabetes mellitus. Diabetes Metab Syndr Obes. 2009 Jun 17;2:73-82. doi: 10.2147/dmsott.s3407. PMID: 21437120; PMCID: PMC3048015.
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Diabetes Metab Syndr Obes. 2009 Jun 17;2:73-82. doi: 10.2147/dmsott.s3407.

Management of gestational diabetes mellitus.

Diabetes, metabolic syndrome and obesity : targets and therapy

Annunziata Lapolla, Maria Grazia Dalfrà, Domenico Fedele

Affiliations

  1. Department of Medical and Surgical Sciences, Padova University, Italy.

PMID: 21437120 PMCID: PMC3048015 DOI: 10.2147/dmsott.s3407

Abstract

The incidence of gestational diabetes mellitus (GDM) is on the increase and, if not diagnosed, managed and treated adequately, can have unfavorable maternal and fetal outcomes. Several studies have shown that glycemic values considered as adequate in the past when monitoring GDM failed to contain these adverse outcomes and randomized trials are needed to ascertain whether these targets should be lowered. Dietary restrictions remain the mainstay of GDM management and suitable physical exercise can help too. The use of rapid-acting insulin analogues (lispro and aspart) are novel treatments for improving metabolic control by reducing postprandial glycemia, while long-acting insulin analogues need to be evaluated by further studies for safety in clinical use before they can be prescribed. Numerous studies have found glyburide and metformin safe in women with GDM but more randomized controlled trials are needed, with a long-term follow-up of mother and child, to confirm these results.

Keywords: fetal complications; gestational diabetes; glucose management; maternal complications; obstetric management

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