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Martins AS, Olmos D, Missiaglia E, et al. Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives. Sarcoma. 2011;2011:209736doi: 10.1155/2011/209736.
Martins, A. S., Olmos, D., Missiaglia, E., & Shipley, J. (2011). Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives. Sarcoma, 2011209736. https://doi.org/10.1155/2011/209736
Martins, Ana Sofia, et al. "Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives." Sarcoma vol. 2011 (2011): 209736. doi: https://doi.org/10.1155/2011/209736
Martins AS, Olmos D, Missiaglia E, Shipley J. Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives. Sarcoma. 2011;2011:209736. doi: 10.1155/2011/209736. Epub 2011 Mar 03. PMID: 21437217; PMCID: PMC3061277.
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Sarcoma. 2011;2011:209736. doi: 10.1155/2011/209736. Epub 2011 Mar 03.

Targeting the insulin-like growth factor pathway in rhabdomyosarcomas: rationale and future perspectives.

Sarcoma

Ana Sofia Martins, David Olmos, Edoardo Missiaglia, Janet Shipley

Affiliations

  1. Molecular Cytogenetics, The Institute of Cancer Research, 15 Cotswold Road Sutton, Surrey SM2 5NG, UK.

PMID: 21437217 PMCID: PMC3061277 DOI: 10.1155/2011/209736

Abstract

Rhabdomyosarcomas (RMS) are a heterogeneous group of tumors that share features of skeletal myogenesis and represent the most common pediatric soft tissue sarcoma. Even though significant advances have been achieved in RMS treatment, prognosis remains very poor for many patients. Several elements of the Insulin-like Growth Factor (IGF) pathway are involved in sarcomas, including RMS. The IGF2 ligand is highly expressed in most, if not all, RMS, and frequent overexpression of the receptor IGF1R is also found. This is confirmed here through mining expression profiling data of a large series of RMS samples. IGF signaling is implicated in the genesis, growth, proliferation, and metastasis of RMS. Blockade of this pathway is therefore a potential therapeutic strategy for the treatment of RMS. In this paper we examine the biological rationale for targeting the IGF pathway in RMS as well as the current associated preclinical and clinical experience.

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