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Duan WJ, Zhang FK, Ou XJ, et al. [The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]. Zhonghua Gan Zang Bing Za Zhi. 2011;19(2):118-20doi: 10.3760/cma.j.issn.1007-3418.2011.02.011.
Duan, W. J., Zhang, F. K., Ou, X. J., Zhang, T., Wang, X. M., Wang, Y., Cui, Y., Zhao, X. Y., & Jia, J. D. (2011). [The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 19(2), 118-20. https://doi.org/10.3760/cma.j.issn.1007-3418.2011.02.011
Duan, Wei-Jia, et al. "[The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]." Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology vol. 19,2 (2011): 118-20. doi: https://doi.org/10.3760/cma.j.issn.1007-3418.2011.02.011
Duan WJ, Zhang FK, Ou XJ, Zhang T, Wang XM, Wang Y, Cui Y, Zhao XY, Jia JD. [The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]. Zhonghua Gan Zang Bing Za Zhi. 2011 Feb;19(2):118-20. doi: 10.3760/cma.j.issn.1007-3418.2011.02.011. Chinese. PMID: 21492515.
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Zhonghua Gan Zang Bing Za Zhi. 2011 Feb;19(2):118-20. doi: 10.3760/cma.j.issn.1007-3418.2011.02.011.

[The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

[Article in Chinese]
Wei-Jia Duan, Fu-Kui Zhang, Xiao-Juan Ou, Tao Zhang, Xiao-Ming Wang, Yu Wang, Yan Cui, Xin-Yan Zhao, Ji-Dong Jia

Affiliations

  1. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

PMID: 21492515 DOI: 10.3760/cma.j.issn.1007-3418.2011.02.011

Abstract

To observe the characteristics of primary biliary cirrhosis (PBC) with a suboptimal biochemical response to ursodeoxycholic acid. A total of 38 Chinse PBC patients (5 male patients, 33 female patients, average age 55 years old) with treatment of ursodeoxycholic acid in our hospital from January 1999 to January 2009 were erolled and studied retrospectively. 17 suboptimal biochemical responders mainly presented with liver diseases related symptoms including jaundice (41.1%), fatigue, anorexia (23.5%), edema and abdominal distension (11.7%). 21 good biochemical responders mainly presented with abnormal liver function tests without symptoms. The suboptimal biochemical responders had significantly higher baseline levels of total serum bilirubin, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, immunoglobulin G and globulin as compared to the good biochemical responsers. There were no differences in gender, age and the dose of UDCA. PBC patients with liver diseases related symptoms, marked abnormal liver tests and characteristics of autoimmune hepatitis may have a suboptimal biochemical response to ursodeoxycholic acid treatment.

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