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Adv Hematol. 2011;2011:347137. doi: 10.1155/2011/347137. Epub 2011 Mar 22.

Micro-RNA Expression and Function in Lymphomas.

Advances in hematology

Sukhinder K Sandhu, Carlo M Croce, Ramiro Garzon

Affiliations

  1. Department of Molecular Virology, Immunology and Medical Genetics, Molecular and Cellular Developmental Biology Program, The Ohio State University Medical Center, Columbus, OH 43210, USA.

PMID: 21461378 PMCID: PMC3063410 DOI: 10.1155/2011/347137

Abstract

The recent discovery of microRNAs (miRNAs) has introduced a new layer of complexity to the process of gene regulation. MiRNAs are essential for cellular function, and their dysregulation often results in disease. Study of miRNA expression and function in animal models and human lymphomas has improved our knowledge of the pathogenesis of this heterogeneous disease. In this paper, we attempt to describe the expression of miRNAs and their function in lymphomas and discuss potential miRNA-based therapies in the diagnosis and treatment of lymphomas.

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