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Int J Oncol. 1995 Jan;6(1):27-9.

In frame deletion of intron-7 in the p53 gene in a human tonsil tumor.

International journal of oncology

K Magnusson, Z Berke, E Munckwikland, I Lewensohnfuchs, G Klein, T Dallianis, K Wiman

Affiliations

  1. HUDDINGE HOSP,KAROLINSKA INST,DEPT IMMUNOL,S-14186 HUDDINGE,SWEDEN. HUDDINGE HOSP,KAROLINSKA INST,DEPT MICROBIOL,S-14186 HUDDINGE,SWEDEN. KAROLINSKA HOSP,DEPT OTORHINOLARYNGOL,S-10401 STOCKHOLM,SWEDEN. HUDDINGE HOSP,KAROLINSKA INST,DEPT PATHOL,S-14186 HUDDINGE,SWEDEN. HUDDINGE HOSP,KAROLINSKA INST,DEPT INFECT DIS,S-14186 HUDDINGE,SWEDEN.

PMID: 21556496

Abstract

We here report a unique intron deletion in the p53 gene. Analysis of a human tonsil tumor that expressed elevated levels of p53 showed a deletion of the entire intron 7 in one of the p53 alleles, leaving the coding sequence intact. The significance of the intron 7 deletion for the development of the tonsil tumor is discussed.

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