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Mrozek K, Arthur D, Karakousis C, et al. Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. Int J Oncol. 1995;6(3):531-8doi: 10.3892/ijo.6.3.531.
Mrozek, K., Arthur, D., Karakousis, C., Koduru, P., Lebeau, M., Pettenati, M., Tantravahi, R., Mrozek, E., Perezmesa, C., Rao, U., Frankel, S., Davey, F., & Bloomfield, C. (1995). Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. International journal of oncology, 6(3), 531-8. https://doi.org/10.3892/ijo.6.3.531
Mrozek, K, et al. "Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia." International journal of oncology vol. 6,3 (1995): 531-8. doi: https://doi.org/10.3892/ijo.6.3.531
Mrozek K, Arthur D, Karakousis C, Koduru P, Lebeau M, Pettenati M, Tantravahi R, Mrozek E, Perezmesa C, Rao U, Frankel S, Davey F, Bloomfield C. Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. Int J Oncol. 1995 Mar;6(3):531-8. doi: 10.3892/ijo.6.3.531. PMID: 21556567.
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Int J Oncol. 1995 Mar;6(3):531-8. doi: 10.3892/ijo.6.3.531.

Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia.

International journal of oncology

K Mrozek, D Arthur, C Karakousis, P Koduru, M Lebeau, M Pettenati, R Tantravahi, E Mrozek, C Perezmesa, U Rao, S Frankel, F Davey, C Bloomfield

Affiliations

  1. ROSWELL PK CANC INST,DEPT SURG ONCOL,BUFFALO,NY 14263. ROSWELL PK CANC INST,DEPT PATHOL,BUFFALO,NY 14263. UNIV MINNESOTA,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455. N SHORE UNIV HOSP,DEPT LABS,MANHASSET,NY 11030. UNIV CHICAGO,MED CTR,CHICAGO,IL 60637. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PEDIAT,WINSTON SALEM,NC 27157. DANA FARBER CANC INST,BOSTON,MA 02115. SUNY HLTH SCI CTR,SYRACUSE,NY 13210.

PMID: 21556567 DOI: 10.3892/ijo.6.3.531

Abstract

An unbalanced translocation between chromosomes 1 and 16, der(16)t(1;16), resulting in trisomy 1q and loss of genetic material from 16q, has been thus far suggested to constitute a nonrandom secondary abnormality in two types of closely related solid tumors - Ewing sarcoma and peripheral primitive neuroepithelial tumor (PNET). We report on three cases of soft tissue tumors, a myxoid liposarcoma, a PNET and a rhabdomyosarcoma, and four cases of hematologic disorders, two acute lymphoblastic leukemias (ALL), an acute mixed leukemia and a refractory anemia, that in addition to primary chromosome abnormalities displayed the presence of the der(16)t(1;16). All three cases of acute leukemia were Philadelphia (Ph) chromosome-positive and all displayed both lymphoid and myeloid antigens. Our results and review of the literature indicate that the occurrence of der(16)t(1;16) is not limited to Ewing sarcoma and PNET, but that acquisition of this abnormality may represent a more general pathway of clonal evolution in several different tumor types including Ph chromosome-positive ALL, myxoid liposarcoma, rhabdomyosarcoma, breast cancer, endometrial adenocarcinoma, myelodysplastic syndromes, acute myeloid leukemia, retinoblastoma, and Wilms' tumor.

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