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Pucciminafra I, Luparello C, Aquino A, et al. Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds. Int J Oncol. 1995;6(5):1015-20doi: 10.3892/ijo.6.5.1015.
Pucciminafra, I., Luparello, C., Aquino, A., Basirico, L., Minafra, S., Franc, S., Yakovlev, L., & Shoshan, S. (1995). Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds. International journal of oncology, 6(5), 1015-20. https://doi.org/10.3892/ijo.6.5.1015
Pucciminafra, I, et al. "Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds." International journal of oncology vol. 6,5 (1995): 1015-20. doi: https://doi.org/10.3892/ijo.6.5.1015
Pucciminafra I, Luparello C, Aquino A, Basirico L, Minafra S, Franc S, Yakovlev L, Shoshan S. Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds. Int J Oncol. 1995 May;6(5):1015-20. doi: 10.3892/ijo.6.5.1015. PMID: 21556633.
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Int J Oncol. 1995 May;6(5):1015-20. doi: 10.3892/ijo.6.5.1015.

Of/Lb collagen promotes chemoinvasion of breast-cancer cells and directs epithelial-cell migration into granulation-tissue of experimental dermal wounds.

International journal of oncology

I Pucciminafra, C Luparello, A Aquino, L Basirico, S Minafra, S Franc, L Yakovlev, S Shoshan

Affiliations

  1. UNIV PALERMO,CTR ONCOBIOL SPERIMENTALE,I-91028 PALERMO,ITALY. UNIV PALERMO,IST ISTOL & EMBRIOL,I-91028 PALERMO,ITALY. INST BIOL & CHIM PROT,CNRS,UPR 412,LYON 07,FRANCE. HEBREW UNIV JERUSALEM,HADASSAH MED SCH,CONNECT TISSUE RES LABS,JERUSALEM,ISRAEL.

PMID: 21556633 DOI: 10.3892/ijo.6.5.1015

Abstract

OF/LB collagen is a recently described once-fetal form of collagen, with laminin-binding properties, composed of three alpha(1)(I)-sized chains, one of which displaying an unusually acidic pI. This collagen appears able to direct the migration of breast cancer cells through Matrigel, and of injury-activated epithelial cells into the underlying granulation stromal tissue. The effect exerted by OF/LB collagen in vitro appears preferentially linked to its acidic chain. The data reported strongly support the hypothesis that the presence and accumulation of OF/LB collagen in cancer may play a fundamental role in the invasive growth.

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