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Uckert W, Walther W, Hummel O. Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. Int J Oncol. 1995;6(5):1027-31doi: 10.3892/ijo.6.5.1027.
Uckert, W., Walther, W., & Hummel, O. (1995). Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. International journal of oncology, 6(5), 1027-31. https://doi.org/10.3892/ijo.6.5.1027
Uckert, W, et al. "Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines." International journal of oncology vol. 6,5 (1995): 1027-31. doi: https://doi.org/10.3892/ijo.6.5.1027
Uckert W, Walther W, Hummel O. Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines. Int J Oncol. 1995 May;6(5):1027-31. doi: 10.3892/ijo.6.5.1027. PMID: 21556635.
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Int J Oncol. 1995 May;6(5):1027-31. doi: 10.3892/ijo.6.5.1027.

Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.

International journal of oncology

W Uckert, W Walther, O Hummel

PMID: 21556635 DOI: 10.3892/ijo.6.5.1027

Abstract

Northern slot blot hybridization and immunohistochemical staining were applied for the characterization of tumor necrosis factor alpha (TNF)-transduced human colon carcinoma cell lines. A significant decrease in the CEA-specific mRNA and protein was observed in TNF-transduced tumor cells LS174T and LoVo while other probes (c-myc, K-ras, c-jun, p53, TGF alpha) as well as anti-K-ras- and anti-p53-antibodies failed to detect differences between cytokine-transduced and parental tumor cells.

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