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Goto H, Hagiwara S, Hirai R, et al. Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy. Rare Tumors. 2011;3(1):e11doi: 10.4081/rt.2011.e11.
Goto, H., Hagiwara, S., Hirai, R., Miyama, T., Honda, H., Tagashira, A., Iizuka, T., Mochizuki, M., Teruya, K., Kikuchi, Y., Oka, S., & Miwa, A. (2011). Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy. Rare tumors, 3(1), e11. https://doi.org/10.4081/rt.2011.e11
Goto, Hiroki, et al. "Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy." Rare tumors vol. 3,1 (2011): e11. doi: https://doi.org/10.4081/rt.2011.e11
Goto H, Hagiwara S, Hirai R, Miyama T, Honda H, Tagashira A, Iizuka T, Mochizuki M, Teruya K, Kikuchi Y, Oka S, Miwa A. Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy. Rare Tumors. 2011 Mar 30;3(1):e11. doi: 10.4081/rt.2011.e11. PMID: 21464873; PMCID: PMC3070448.
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Rare Tumors. 2011 Mar 30;3(1):e11. doi: 10.4081/rt.2011.e11.

Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy.

Rare tumors

Hiroki Goto, Shotaro Hagiwara, Risen Hirai, Takahiko Miyama, Haruhito Honda, Amane Tagashira, Toshihiko Iizuka, Makoto Mochizuki, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka, Akiyoshi Miwa

Affiliations

  1. Division of Hematology, Internal Medicine, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo;

PMID: 21464873 PMCID: PMC3070448 DOI: 10.4081/rt.2011.e11

Abstract

Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation.

Keywords: AIDS.; autologous stem cell transplantation; plasmablastic lymphoma

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