Display options
Cite
Kim YC, Quan FS, Song JM, et al. Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles. Procedia Vaccinol. 2010;2(1):15-19doi: 10.1016/j.provac.2010.03.004.
Kim, Y. C., Quan, F. S., Song, J. M., Vunnava, A., Yoo, D. G., Park, K. M., Compans, R. W., Kang, S. M., & Prausnitz, M. R. (2010). Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles. Procedia in vaccinology, 2(1), 15-19. https://doi.org/10.1016/j.provac.2010.03.004
Kim, Yeu-Chun, et al. "Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles." Procedia in vaccinology vol. 2,1 (2010): 15-19. doi: https://doi.org/10.1016/j.provac.2010.03.004
Kim YC, Quan FS, Song JM, Vunnava A, Yoo DG, Park KM, Compans RW, Kang SM, Prausnitz MR. Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles. Procedia Vaccinol. 2010;2(1):15-19. doi: 10.1016/j.provac.2010.03.004. PMID: 21528098; PMCID: PMC3082143.
Copy Download .nbib Format: NLM
Share it on

Procedia Vaccinol. 2010;2(1):15-19. doi: 10.1016/j.provac.2010.03.004.

Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles.

Procedia in vaccinology

Yeu-Chun Kim, Fu-Shi Quan, Jae-Min Song, Aswani Vunnava, Dae-Goon Yoo, Kyoung-Mi Park, Richard W Compans, Sang-Moo Kang, Mark R Prausnitz

Affiliations

  1. School of Chemical and Biomolecular Engineering, Georgia Institute of Technology.

PMID: 21528098 PMCID: PMC3082143 DOI: 10.1016/j.provac.2010.03.004

Abstract

Morbidity and mortality due to seasonal and pandemic influenza could be reduced by simpler vaccination methods that enable improved vaccination coverage. In this study, solid metal microneedles coated with influenza virus-like particle (VLP) vaccine were inserted into skin for intradermal immunization. Microneedles were applied to the skin by hand and designed for simple administration with little or no training. Inclusion of trehalose in the coating formulation significantly increased vaccine stability during coating by maintaining hemagglutination activity. Mice vaccinated with stabilized microneedles developed strong antibody responses comparable to conventional intramuscular vaccination and were fully protected against subsequent viral challenge. Whereas, coating microneedles with a coating solution lacking trehalose led to only partial protection against lethal viral challenge. Therefore, our results show that microneedles coated with trehalose-stabilized VLP vaccine can be a promising tool for improving influenza vaccination.

References

  1. Expert Rev Vaccines. 2007 Jun;6(3):381-90 - PubMed
  2. J Clin Virol. 2009 Jul;45(3):169-73 - PubMed
  3. Vaccine. 2008 Dec 2;26(51):6614-9 - PubMed
  4. Nat Biotechnol. 2008 Nov;26(11):1261-8 - PubMed
  5. J Control Release. 2010 Mar 3;142(2):187-95 - PubMed
  6. Arch Virol. 1975;49(2-3):199-205 - PubMed
  7. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7968-73 - PubMed
  8. Vaccine. 2003 Jan 30;21(7-8):776-80 - PubMed
  9. Vaccine. 2009 Jan 14;27(3):454-9 - PubMed
  10. PLoS One. 2009;4(3):e4773 - PubMed
  11. Expert Rev Vaccines. 2009 Apr;8(4):383-9 - PubMed
  12. PLoS One. 2009 Sep 25;4(9):e7152 - PubMed
  13. J Infect Dis. 2010 Jan 15;201(2):190-8 - PubMed
  14. Vaccine. 2009 Nov 16;27(49):6932-8 - PubMed
  15. Vaccine. 2008 Sep 12;26 Suppl 4:D49-53 - PubMed
  16. J Virol. 2007 Apr;81(7):3514-24 - PubMed

Publication Types

Grant support