Display options
Cite
Tugnoli V, Tosi M, Barbarella G, et al. In vitro and in vivo MRS study of human glioma metabolites. Int J Oncol. 1997;11(2):319-24doi: 10.3892/ijo.11.2.319.
Tugnoli, V., Tosi, M., Barbarella, G., Ricci, R., Calbucci, F., & Bertoluzza, A. (1997). In vitro and in vivo MRS study of human glioma metabolites. International journal of oncology, 11(2), 319-24. https://doi.org/10.3892/ijo.11.2.319
Tugnoli, V, et al. "In vitro and in vivo MRS study of human glioma metabolites." International journal of oncology vol. 11,2 (1997): 319-24. doi: https://doi.org/10.3892/ijo.11.2.319
Tugnoli V, Tosi M, Barbarella G, Ricci R, Calbucci F, Bertoluzza A. In vitro and in vivo MRS study of human glioma metabolites. Int J Oncol. 1997 Aug;11(2):319-24. doi: 10.3892/ijo.11.2.319. PMID: 21528217.
Copy Download .nbib Format: NLM
Share it on

Int J Oncol. 1997 Aug;11(2):319-24. doi: 10.3892/ijo.11.2.319.

In vitro and in vivo MRS study of human glioma metabolites.

International journal of oncology

V Tugnoli, M Tosi, G Barbarella, R Ricci, F Calbucci, A Bertoluzza

Affiliations

  1. CNR,IST CITOMORFOL NORMALE & PATOL,I-40136 BOLOGNA,ITALY. CNR,ICOCEA,AREA RIC,I-40129 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,SERV NEURORADIOL,I-40139 BOLOGNA,ITALY. UNIV BOLOGNA,OSPED BELLARIA,DIV NEUROCHIRURG,I-40139 BOLOGNA,ITALY.

PMID: 21528217 DOI: 10.3892/ijo.11.2.319

Abstract

In this study an in vitro multinuclear magnetic resonance spectroscopy (MRS) characterization of water soluble metabolites and of the lipid fraction obtained from 19 human gliomas (12 glioblastomas, 3 anaplastic astrocytomas, 2 anaplastic oligodendrogliomas and 2 oligodendrogliomas) with a total of 27 surgical specimens, is reported. Moreover, some in vivo H-1 MRS results are shown. The regional metabolic heterogeneity of glioblastomas, according to their morphological heterogeneity, is documented. For glioblastomas a specific in vitro H-1 MRS metabolite profile cannot be defined. Low and high grade oligodendrogliomas showed characteristic choline/creatine and alanine/creatine metabolite ratios. The spectroscopical characterization of histopathological factors concerning malignant gliomas is shown.

Publication Types