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Horton JA, Strauss JA, Allen MJ, et al. Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model. Sarcoma. 2011;2011:815190doi: 10.1155/2011/815190.
Horton, J. A., Strauss, J. A., Allen, M. J., & Damron, T. A. (2011). Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model. Sarcoma, 2011815190. https://doi.org/10.1155/2011/815190
Horton, Jason A, et al. "Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model." Sarcoma vol. 2011 (2011): 815190. doi: https://doi.org/10.1155/2011/815190
Horton JA, Strauss JA, Allen MJ, Damron TA. Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model. Sarcoma. 2011;2011:815190. doi: 10.1155/2011/815190. Epub 2011 Apr 17. PMID: 21559211; PMCID: PMC3087963.
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Sarcoma. 2011;2011:815190. doi: 10.1155/2011/815190. Epub 2011 Apr 17.

Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model.

Sarcoma

Jason A Horton, Judith A Strauss, Matthew J Allen, Timothy A Damron

Affiliations

  1. Department of Orthopaedic Surgery, Musculoskeletal Sciences Research Center, Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, NY 13210, USA.

PMID: 21559211 PMCID: PMC3087963 DOI: 10.1155/2011/815190

Abstract

Radiotherapy used in the treatment of pediatric musculoskeletal sarcomas may result in crippling defects of skeletal growth. Several radioprotective strategies have shown potential for preserving function of the irradiated epiphysis but have not been evaluated in a tumor-bearing animal model. We developed two bioluminescent human rhabdomyosarcoma cell lines that were used to establish xenograft tumors in skeletally immature mice. Bioluminescence imaging and radiography allowed serial evaluation of tumor growth and tibial elongation following localized radiotherapy. High-dose (10 Gy) radiotherapy significantly reduced tumor growth velocity and prolonged the median survival of tumor-bearing mice but also resulted in a significant 3.3% shortening of the irradiated limb. Exposure to a lower, 2 Gy dose resulted in 4.1% decrease in limb length but did not extend survival. This new model provides a clinically relevant means to test the efficacy and safety of novel radioprotectant and radiorecovery strategies for use in this context.

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