Display options
Cite
Cheema-Dhadli S, Chong CK, Alazmi M, et al. Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?. Electrolyte Blood Press. 2010;8(1):10-7doi: 10.5049/EBP.2010.8.1.10.
Cheema-Dhadli, S., Chong, C. K., Alazmi, M., Kamel, K. S., & Halperin, M. L. (2010). Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?. Electrolyte & blood pressure : E & BP, 8(1), 10-7. https://doi.org/10.5049/EBP.2010.8.1.10
Cheema-Dhadli, Surinder, et al. "Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?." Electrolyte & blood pressure : E & BP vol. 8,1 (2010): 10-7. doi: https://doi.org/10.5049/EBP.2010.8.1.10
Cheema-Dhadli S, Chong CK, Alazmi M, Kamel KS, Halperin ML. Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?. Electrolyte Blood Press. 2010 Jun;8(1):10-7. doi: 10.5049/EBP.2010.8.1.10. Epub 2010 Jun 30. PMID: 21468192; PMCID: PMC3041496.
Copy Download .nbib Format: NLM
Share it on

Electrolyte Blood Press. 2010 Jun;8(1):10-7. doi: 10.5049/EBP.2010.8.1.10. Epub 2010 Jun 30.

Is there escape from renal actions of vasopressin in rats with a hyponatremia for greater than 48 hours?.

Electrolyte & blood pressure : E & BP

Surinder Cheema-Dhadli, Chee Keong Chong, Mohammad Alazmi, Kamel S Kamel, Mitchell L Halperin

Affiliations

  1. Renal Divisions, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

PMID: 21468192 PMCID: PMC3041496 DOI: 10.5049/EBP.2010.8.1.10

Abstract

Escape from the renal actions of vasopressin is said to occur in rats with chronic hyponatremia. Our objective was to provide specific evidence to test this hypothesis. Hence the osmolality in the excised renal papilla and in simultaneously voided urine (U(Osm)) was measured in rats with and without hyponatremia. To induce hyponatremia, rats were fed low-electrolyte chow for 6 days. In the first 3 days, water was provided ad lib. On days 4 to 6, a long acting vasopressin preparation (dDAVP) was given every 8 hours to induce water retention. The hyponatremic rats drank 21 mL 5% sucrose on day 4 and 6 mL on day 5. On the morning of day 6, these rats were given 10 mL of 5% glucose in water (D5W) by the intraperitoneal route at 09:00 hour and at 11:00 hour. Analyses were performed in blood, urine, and the excised renal papilla at 13:00 hour on day 6. The concentration of Na(+) in plasma (P(Na)) in rats without intraperitoneal D5W was 140±1 mEq/L (n=7) whereas it was 112±3 mEq/L in the hyponatremic group (n=12). The hyponatremic rats had a higher osmolality in the excised papillary (1,915±117 mOsm/kg H(2)O) than the U(Osm) (1,528±176 mOsm/kg H(2)O, P<0.05). One explanation for this difference is that the rats escaped from the renal action of vasopressin. Nevertheless, based on a quantitative analysis, other possibilities will be considered.

Keywords: aquaporins; basal water permeability; concentration of the urine; vasopressins

References

  1. Can J Physiol Pharmacol. 1993 Feb;71(2):120-7 - PubMed
  2. Kidney Int. 1980 Oct;18(4):419-31 - PubMed
  3. Kidney Int. 1998 Jan;53(1):159-66 - PubMed
  4. Kidney Int. 2001 Oct;60(4):1608-10 - PubMed
  5. J Am Soc Nephrol. 1999 Oct;10(10):2067-75 - PubMed
  6. Am J Physiol. 1994 Aug;267(2 Pt 2):R554-60 - PubMed
  7. Am J Physiol. 1998 Jun;274(6):F1161-6 - PubMed
  8. Am J Physiol. 1985 Apr;248(4 Pt 2):F607-15 - PubMed
  9. J Am Soc Nephrol. 2005 Oct;16(10):2852-63 - PubMed
  10. Am J Physiol Renal Physiol. 2004 Nov;287(5):F1076-83 - PubMed
  11. Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R354-62 - PubMed
  12. Endocrinology. 2000 Jan;141(1):307-14 - PubMed
  13. J Clin Invest. 1997 Apr 15;99(8):1852-63 - PubMed
  14. J Clin Invest. 1990 Oct;86(4):1023-9 - PubMed
  15. J Am Soc Nephrol. 2001 Feb;12(2):207-217 - PubMed

Publication Types