Display options
Cite
Judware R, Culp L. Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits. Oncol Rep. 1997;4(2):433-7doi: 10.3892/or.4.2.433.
Judware, R., & Culp, L. (1997). Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits. Oncology reports, 4(2), 433-7. https://doi.org/10.3892/or.4.2.433
Judware, R, and Culp, L. "Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits." Oncology reports vol. 4,2 (1997): 433-7. doi: https://doi.org/10.3892/or.4.2.433
Judware R, Culp L. Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits. Oncol Rep. 1997 Mar-Apr;4(2):433-7. doi: 10.3892/or.4.2.433. PMID: 21590074.
Copy Download .nbib Format: NLM
Share it on

Oncol Rep. 1997 Mar-Apr;4(2):433-7. doi: 10.3892/or.4.2.433.

Persistent alpha 1 integrin subunit expression in human neuroblastoma cell lines which overexpress N-myc and downregulate other integrin subunits.

Oncology reports

R Judware, L Culp

Affiliations

  1. CASE WESTERN RESERVE UNIV,SCH MED,DEPT MOL BIOL & MICROBIOL,CLEVELAND,OH 44106.

PMID: 21590074 DOI: 10.3892/or.4.2.433

Abstract

Neuroblastoma is characterized by amplification and overexpression of N-myc. N-myc down-regulates expression of the beta 1 integrin extracellular matrix receptor, however, some beta 1 was found on the surface of N-myc overexpressing neuroblastoma cell lines. It was determined that the alpha 1 subunit is expressed in the cells, associates with beta 1 and is present on the cell surface. Interestingly, the level of alpha 1 was reduced marginally when compared to beta 1. Finally, overexpression of N-myc alters cell morphology on extracellular matrix proteins with persistence of alpha 1 beta 1-dependent responses. Our work supports the conclusion that altered integrin expression may be an important factor in human neuroblastoma.

Publication Types