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Gembitsky D, Popova N, Antokhin A, et al. The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. Oncol Rep. 1996;3(2):333-8doi: 10.3892/or.3.2.333.
Gembitsky, D., Popova, N., Antokhin, A., Podusov, Y., Karpets, L., Adrianov, N., & Romanov, Y. (1996). The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. Oncology reports, 3(2), 333-8. https://doi.org/10.3892/or.3.2.333
Gembitsky, D, et al. "The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice." Oncology reports vol. 3,2 (1996): 333-8. doi: https://doi.org/10.3892/or.3.2.333
Gembitsky D, Popova N, Antokhin A, Podusov Y, Karpets L, Adrianov N, Romanov Y. The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. Oncol Rep. 1996 Mar;3(2):333-8. doi: 10.3892/or.3.2.333. PMID: 21594369.
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Oncol Rep. 1996 Mar;3(2):333-8. doi: 10.3892/or.3.2.333.

The Ehrlich ascites carcinoma (EAC) contains 300-500 Da inhibitor(s) suppressing DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice.

Oncology reports

D Gembitsky, N Popova, A Antokhin, Y Podusov, L Karpets, N Adrianov, Y Romanov

Affiliations

  1. RUSSIAN STATE MED UNIV, FAC MED BIOL, DEPT MED BIOL, MOSCOW 117513, RUSSIA. RUSSIAN STATE MED UNIV, LAB DRUG ECOL TOXICOL & METAB, MOSCOW 117513, RUSSIA.

PMID: 21594369 DOI: 10.3892/or.3.2.333

Abstract

A protein preparation obtained from the Ehrlich ascites carcinoma (EAC) by acetone precipitation, water extraction and subsequent two-step alcohol fractionation reduced significantly EAC cell proliferation in vivo and in vitro. The preparation was found to contain a low molecular-weight growth-inhibitory activity, suppressing both DNA synthesis in cultured EAC cells and EAC cell division in tumor-bearing mice. The approximate molecular weight of this inhibitory component(s) is about 300-500 Da, corresponding to oligopeptide molecule(s).

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