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Moon R, Rao K, Detrisac C, et al. Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination. Int J Oncol. 1994;4(3):661-7doi: 10.3892/ijo.4.3.661.
Moon, R., Rao, K., Detrisac, C., Kelloff, G., Steele, V., & Doody, L. (1994). Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination. International journal of oncology, 4(3), 661-7. https://doi.org/10.3892/ijo.4.3.661
Moon, R, et al. "Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination." International journal of oncology vol. 4,3 (1994): 661-7. doi: https://doi.org/10.3892/ijo.4.3.661
Moon R, Rao K, Detrisac C, Kelloff G, Steele V, Doody L. Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination. Int J Oncol. 1994 Mar;4(3):661-7. doi: 10.3892/ijo.4.3.661. PMID: 21566974.
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Int J Oncol. 1994 Mar;4(3):661-7. doi: 10.3892/ijo.4.3.661.

Chemoprevention of respiratory-tract neoplasia in the hamster by oltipraz, alone and in combination.

International journal of oncology

R Moon, K Rao, C Detrisac, G Kelloff, V Steele, L Doody

Affiliations

  1. IIT,CHICAGO,IL 60616. NCI,CHEMOPREVENT INVEST STUDIES BRANCH,BETHESDA,MD 20892. CSS ASSOCIATES,PALO ALTO,CA 94301.

PMID: 21566974 DOI: 10.3892/ijo.4.3.661

Abstract

Two doses of oltipraz (300, 600 mg/kg diet) and alpha-difluoromethylornithine DFMO; 1600, 3200 mg/kg diet), alone and in combinations with N-(4-hydroxyphenyl) retinamide (4-HPR; 98, 196 mg/kg diet) and/or beta-carotene (3, 1.5 mg; sc, 2x/week), were investigated for prevention of hamster respiratory carcinogenesis. After 25 weeks, only high dose oltipraz (-100%) inhibited the incidence of DEN-induced (17.8 mg/kg BW, sc, 2x/week, 20 weeks) bronchial carcinomas when given alone. Low dose oltipraz (-34%, n.s.) synergistically decreased carcinoma incidence in combinations with 4-HPR (-80%), beta-carotene (-90%) or both (-100%). Other effective combinations were low dose DFMO + beta-carotene (-64%) and high dose DFMO with 4-HPR (-56%), beta-carotene (-63%) or both (-67%).

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