Display options
Cite
Witters L, Almondhiry H, Matthews Y, et al. Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies. Int J Oncol. 1994;4(4):943-50doi: 10.3892/ijo.4.4.943.
Witters, L., Almondhiry, H., Matthews, Y., Walker, R., Langton, B., Dasch, J., & Lipton, A. (1994). Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies. International journal of oncology, 4(4), 943-50. https://doi.org/10.3892/ijo.4.4.943
Witters, L, et al. "Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies." International journal of oncology vol. 4,4 (1994): 943-50. doi: https://doi.org/10.3892/ijo.4.4.943
Witters L, Almondhiry H, Matthews Y, Walker R, Langton B, Dasch J, Lipton A. Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies. Int J Oncol. 1994 Apr;4(4):943-50. doi: 10.3892/ijo.4.4.943. PMID: 21567004.
Copy Download .nbib Format: NLM
Share it on

Int J Oncol. 1994 Apr;4(4):943-50. doi: 10.3892/ijo.4.4.943.

Transforming growth-factor-alpha and factor-beta(1) levels in plasma and effusions from patients with cancer or hematologic malignancies.

International journal of oncology

L Witters, H Almondhiry, Y Matthews, R Walker, B Langton, J Dasch, A Lipton

Affiliations

  1. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT MED,DIV MED ONCOL,HERSHEY,PA 17033. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT BIOSTAT,HERSHEY,PA 17033. TRITON DIAGNOST INC,ALAMEDA,CA 94501. BERLEX BIOSCI INC,ALAMEDA,CA 94501. CELTRIX LABS INC,PALO ALTO,CA 94303.

PMID: 21567004 DOI: 10.3892/ijo.4.4.943

Abstract

Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.

Publication Types