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Dancona S, Mazzo M. Morphologic changes of Doxorubicin-sensitive and resistant lovo cells treated in-vitro by calcium channels blockers. Oncol Rep. 1995;2(3):417-21doi: 10.3892/or.2.3.417.
Dancona, S., & Mazzo, M. (1995). Morphologic changes of Doxorubicin-sensitive and resistant lovo cells treated in-vitro by calcium channels blockers. Oncology reports, 2(3), 417-21. https://doi.org/10.3892/or.2.3.417
Dancona, S, and Mazzo, M. "Morphologic changes of Doxorubicin-sensitive and resistant lovo cells treated in-vitro by calcium channels blockers." Oncology reports vol. 2,3 (1995): 417-21. doi: https://doi.org/10.3892/or.2.3.417
Dancona S, Mazzo M. Morphologic changes of Doxorubicin-sensitive and resistant lovo cells treated in-vitro by calcium channels blockers. Oncol Rep. 1995 May;2(3):417-21. doi: 10.3892/or.2.3.417. PMID: 21597749.
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Oncol Rep. 1995 May;2(3):417-21. doi: 10.3892/or.2.3.417.

Morphologic changes of Doxorubicin-sensitive and resistant lovo cells treated in-vitro by calcium channels blockers.

Oncology reports

S Dancona, M Mazzo

PMID: 21597749 DOI: 10.3892/or.2.3.417

Abstract

A morphological analysis by scanning electron microscopy (SEM) of the effect of two Ca++ channel blockers (verapamil and dilazep) on LoVo S (doxorubicin sensitive) and LoVo R (doxorubicin resistant) plated together with 3T3 in order to cause an experimental ground of metastasis was performed. Ca++ channel blockers have been previously tested alone and combined with doxorubicin. The increasing effect on the sensitivity of inherently antiblastic drug resistance and their possible role as antimetastatic agent according to the experiments of Tsuruo et al (Cancer Chemother Pharmacol 14: 30-33, 1985) is reported.

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