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Motomura K, Koyama H, Noguchi S, et al. Preoperative detection of C-erbb-2 gene amplification as a predictor of local recurrence after conservative treatment for breast-carcinoma. Oncol Rep. 1995;2(4):563-6doi: 10.3892/or.2.4.563.
Motomura, K., Koyama, H., Noguchi, S., & Inaji, H. (1995). Preoperative detection of C-erbb-2 gene amplification as a predictor of local recurrence after conservative treatment for breast-carcinoma. Oncology reports, 2(4), 563-6. https://doi.org/10.3892/or.2.4.563
Motomura, K, et al. "Preoperative detection of C-erbb-2 gene amplification as a predictor of local recurrence after conservative treatment for breast-carcinoma." Oncology reports vol. 2,4 (1995): 563-6. doi: https://doi.org/10.3892/or.2.4.563
Motomura K, Koyama H, Noguchi S, Inaji H. Preoperative detection of C-erbb-2 gene amplification as a predictor of local recurrence after conservative treatment for breast-carcinoma. Oncol Rep. 1995 Jul;2(4):563-6. doi: 10.3892/or.2.4.563. PMID: 21597776.
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Oncol Rep. 1995 Jul;2(4):563-6. doi: 10.3892/or.2.4.563.

Preoperative detection of C-erbb-2 gene amplification as a predictor of local recurrence after conservative treatment for breast-carcinoma.

Oncology reports

K Motomura, H Koyama, S Noguchi, H Inaji

PMID: 21597776 DOI: 10.3892/or.2.4.563

Abstract

The presence of comedo carcinoma in the intraductal component is an important pathologic feature for predicting local recurrence after breast conserving treatment. Furthermore, the c-erbB-2 gene is frequently overexpressed in comedo carcinoma and it correlates well with gene amplification. This study revealed that 77.0% of the c-erbB-2 amplification positive tumors had intraductal lesions of the comedo type; while only 6.7% of the amplification negative tumors had comedo carcinoma (X(2)=106.6, p<0.0001). Accordingly, when c-erbB-2 amplification is detected in the invasive tumor, intraductal lesions which may co-exist in the tumor are likely to be comedo carcinoma. To predict the presence of comedo type intraductal carcinoma, c-erbB-2 gene amplification was analysed by means of polymerase chain reaction (PCR) from small samples of fine-needle aspiration biopsies. Breast tumors from ten patients were analysed and one had a 3.4-fold amplification of c-erbB-2 gene. The pathological appearance of this case was pure ductal carcinoma in situ with comedo carcinoma. The preoperative detection of c-erbB-2 gene amplification by PCR will be a useful means of selecting patients at high risk for local recurrence after breast conserving treatment.

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