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Facchini G, Tortoriello A, Caponigro F, et al. Neoadjuvant chemotherapy in locally advanced gastric-cancer - preliminary-results of a phase-ii trial with a modified famtx combination. Oncol Rep. 1995;2(5):727-30doi: 10.3892/or.2.5.727.
Facchini, G., Tortoriello, A., Caponigro, F., Benassai, G., Bucci, L., Gesue, G., Sarnella, G., Giglio, D., Persico, G., & Iaffaioli, R. (1995). Neoadjuvant chemotherapy in locally advanced gastric-cancer - preliminary-results of a phase-ii trial with a modified famtx combination. Oncology reports, 2(5), 727-30. https://doi.org/10.3892/or.2.5.727
Facchini, G, et al. "Neoadjuvant chemotherapy in locally advanced gastric-cancer - preliminary-results of a phase-ii trial with a modified famtx combination." Oncology reports vol. 2,5 (1995): 727-30. doi: https://doi.org/10.3892/or.2.5.727
Facchini G, Tortoriello A, Caponigro F, Benassai G, Bucci L, Gesue G, Sarnella G, Giglio D, Persico G, Iaffaioli R. Neoadjuvant chemotherapy in locally advanced gastric-cancer - preliminary-results of a phase-ii trial with a modified famtx combination. Oncol Rep. 1995 Sep;2(5):727-30. doi: 10.3892/or.2.5.727. PMID: 21597805.
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Oncol Rep. 1995 Sep;2(5):727-30. doi: 10.3892/or.2.5.727.

Neoadjuvant chemotherapy in locally advanced gastric-cancer - preliminary-results of a phase-ii trial with a modified famtx combination.

Oncology reports

G Facchini, A Tortoriello, F Caponigro, G Benassai, L Bucci, G Gesue, G Sarnella, D Giglio, G Persico, R Iaffaioli

Affiliations

  1. UNIV NAPLES,MED CLIN 1,I-80131 NAPLES,ITALY. UNIV CAGLIARI,IST MED INTERNA,I-09124 CAGLIARI,ITALY. IST MED LEGALE AM,I-20129 MILAN,ITALY. OSPED LORETO MARE,I-80100 NAPLES,ITALY. OSPED VECCHIO PELLEGRINI,DIV CHIRURG 3,I-80100 NAPLES,ITALY.

PMID: 21597805 DOI: 10.3892/or.2.5.727

Abstract

Twenty-two patients with locally advanced inoperable gastric cancer received neoadjuvant chemotherapy with a modified 5-fluorouracil, doxorubicin, methotrexate (FAMTX) regimen. The patients who achieved at least a stable disease were considered eligible for surgery with curative intent, which was performed in 19 cases. 16 patients (all responsive to neoadjuvant chemotherapy) were rendered disease-free by the combined approach. No treatment-related deaths occurred; grade III leukopenia was observed in only 3 cases. The preliminary results of this study indicate the feasibility of our treatment approach; randomized trials are awaited to properly evaluate the role of neoadjuvant chemotherapy in locally advanced gastric cancer.

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