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Payee H, Chandrasekaran R, Raju GV. Catatonic syndrome : treatment response to Lorazepam. Indian J Psychiatry. 1999;41(1):49-53
Payee, H., Chandrasekaran, R., & Raju, G. V. (1999). Catatonic syndrome : treatment response to Lorazepam. Indian journal of psychiatry, 41(1), 49-53.
Payee, H, et al. "Catatonic syndrome : treatment response to Lorazepam." Indian journal of psychiatry vol. 41,1 (1999): 49-53.
Payee H, Chandrasekaran R, Raju GV. Catatonic syndrome : treatment response to Lorazepam. Indian J Psychiatry. 1999 Jan;41(1):49-53. PMID: 21455353; PMCID: PMC2962282.
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Indian J Psychiatry. 1999 Jan;41(1):49-53.

Catatonic syndrome : treatment response to Lorazepam.

Indian journal of psychiatry

H Payee, R Chandrasekaran, G V Raju

Affiliations

  1. HANIYA PAYEE, M.B.B.S., DPM., Senior Resident, Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry 605006.

PMID: 21455353 PMCID: PMC2962282

Abstract

In a prospective open trial, 30 inpatients with catatonic signs were treated systematically with oral lorazepam (dosage ranging between 3 to 8 mg/d) for a period of 5 days and subsequently with ECT if lorazepam trial failed. Outcome was monitored quantitatively during the treatment phase with Bush-Francis catatonia rating scale. In 21 out of 30 patients (70%), catatonic signs resolved with lorazepam trial. The response to lorazepam on Day 1, predicted the final outcome. Demographic variables, severity of catatonia or length of catatonic syndrome prior to treatment did not have any predictive value. Majority of the patients who showed an unfavourable response, did well with electroconvulsive therapy. A short duration lorazepam administration proved to be a safe and effective treatment for the catatonic syndrome.

Keywords: Catatonia; electroconvulsive therapy; lorazepam

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