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Rodriguez E, Weiss DA, Copp HL. Adherence to antibiotic prophylaxis in children with vesicoureteral reflux. Adv Urol. 2011;2011:134127doi: 10.1155/2011/134127.
Rodriguez, E., Weiss, D. A., & Copp, H. L. (2011). Adherence to antibiotic prophylaxis in children with vesicoureteral reflux. Advances in urology, 2011134127. https://doi.org/10.1155/2011/134127
Rodriguez, Esequiel, et al. "Adherence to antibiotic prophylaxis in children with vesicoureteral reflux." Advances in urology vol. 2011 (2011): 134127. doi: https://doi.org/10.1155/2011/134127
Rodriguez E, Weiss DA, Copp HL. Adherence to antibiotic prophylaxis in children with vesicoureteral reflux. Adv Urol. 2011;2011:134127. doi: 10.1155/2011/134127. Epub 2011 Mar 27. PMID: 21603191; PMCID: PMC3095244.
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Adv Urol. 2011;2011:134127. doi: 10.1155/2011/134127. Epub 2011 Mar 27.

Adherence to antibiotic prophylaxis in children with vesicoureteral reflux.

Advances in urology

Esequiel Rodriguez, Dana A Weiss, Hillary L Copp

Affiliations

  1. UCSF Department of Urology, University of California, 400 Parnassus Ave, A633 San Francisco, CA 94143-0738, USA.

PMID: 21603191 PMCID: PMC3095244 DOI: 10.1155/2011/134127

Abstract

Vesicoureteral reflux (VUR) affects approximately 1% of children and may predispose a child with a bladder infection to develop pyelonephritis and renal scarring. To prevent these potential sequelae, one accepted treatment option for VUR includes low-dose continuous antibiotic prophylaxis (CAP) to maintain urine sterility until the condition resolves. Despite the widespread use of CAP, little data exists regarding adherence to long-term antibiotic therapy. Not only will poor adherence to CAP potentially preclude the intended benefit, but also nonadherence with antibiotic regimens may carry untoward effects including unnecessary treatment changes for presumed antibiotic failure, emergence of resistant organisms, and compromised clinical trial outcomes. We present an overview of medication adherence in children with VUR, discuss possible consequences of nonadherence to antibiotic prophylaxis, and suggest ways to improve adherence. We raise awareness of issues related to nonadherence relevant to healthcare providers, investigators, and the community.

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