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Int J Mol Imaging. 2011;2011:796025. doi: 10.1155/2011/796025. Epub 2011 Apr 05.

Molecular SPECT Imaging: An Overview.

International journal of molecular imaging

Magdy M Khalil, Jordi L Tremoleda, Tamer B Bayomy, Willy Gsell

Affiliations

  1. Biological Imaging Centre, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.

PMID: 21603240 PMCID: PMC3094893 DOI: 10.1155/2011/796025

Abstract

Molecular imaging has witnessed a tremendous change over the last decade. Growing interest and emphasis are placed on this specialized technology represented by developing new scanners, pharmaceutical drugs, diagnostic agents, new therapeutic regimens, and ultimately, significant improvement of patient health care. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) have their signature on paving the way to molecular diagnostics and personalized medicine. The former will be the topic of the current paper where the authors address the current position of the molecular SPECT imaging among other imaging techniques, describing strengths and weaknesses, differences between SPECT and PET, and focusing on different SPECT designs and detection systems. Radiopharmaceutical compounds of clinical as well-preclinical interest have also been reviewed. Moreover, the last section covers several application, of μSPECT imaging in many areas of disease detection and diagnosis.

References

  1. Nucl Med Biol. 2003 Nov;30(8):889-95 - PubMed
  2. NeuroRx. 2005 Apr;2(2):237-49 - PubMed
  3. Phys Med Biol. 2009 May 7;54(9):2635-49 - PubMed
  4. J Nucl Med. 2005 May;46(5):816-22 - PubMed
  5. Phys Med Biol. 2005 Nov 21;50(22):R45-61 - PubMed
  6. J Nucl Med. 2006 May;47(5):868-76 - PubMed
  7. Mol Imaging Biol. 2003 Sep-Oct;5(5):304-11 - PubMed
  8. Circulation. 2004 Nov 23;110(21):3378-83 - PubMed
  9. J Nucl Med. 2008 Oct;49(10):1651-63 - PubMed
  10. J Nucl Med. 2009 Jul;50(7):1147-52 - PubMed
  11. Arch Toxicol. 2005 May;79(5):268-76 - PubMed
  12. Eur J Nucl Med Mol Imaging. 2005 Feb;32(2):211-20 - PubMed
  13. Eur J Nucl Med. 2001 Mar;28(3):266-72 - PubMed
  14. Nature. 1975 Aug 7;256(5517):495-7 - PubMed
  15. Clin Nucl Med. 2008 Jan;33(1):46-8 - PubMed
  16. J Radiol. 2008 Mar;89(3 Pt 2):438-47; quiz 448 - PubMed
  17. J Nucl Med. 2001 Sep;42(9):1368-74 - PubMed
  18. Eur J Nucl Med Mol Imaging. 2004 Jan;31(1):44-51 - PubMed
  19. Neurochem Int. 2008 Feb;52(3):352-62 - PubMed
  20. J Nucl Med. 2009 May;50(5):667-70 - PubMed
  21. J Nucl Med. 1990 Mar;31(3):281-6 - PubMed
  22. Clin Radiol. 2010 Jul;65(7):500-16 - PubMed
  23. J Nucl Med. 2004 Oct;45(10):1759-65 - PubMed
  24. J Nucl Med. 1991 May;32(5):819-24 - PubMed
  25. J Nucl Med. 2008 Jun;49 Suppl 2:129S-48S - PubMed
  26. Nucl Med Biol. 1995 Oct;22(7):875-85 - PubMed
  27. J Nucl Med. 2002 Jul;43(7):933-9 - PubMed
  28. Thromb Res. 1994 Sep 1;75(5):491-501 - PubMed
  29. J Nucl Med. 2000 Apr;41(4):661-81 - PubMed
  30. Curr Cardiol Rep. 2010 Jan;12(1):51-8 - PubMed
  31. Mol Pharm. 2006 Nov-Dec;3(6):717-25 - PubMed
  32. J Cell Biochem Suppl. 2002;39:116-24 - PubMed
  33. J Clin Invest. 2004 Jun;113(12):1684-91 - PubMed
  34. J Am Coll Cardiol. 2008 Nov 11;52(20):1652-60 - PubMed
  35. J Org Chem. 2003 Jan 24;68(2):512-8 - PubMed
  36. J Nucl Med. 2004 Oct;45(10):1688-93 - PubMed
  37. Nucl Med Biol. 2006 Feb;33(2):217-26 - PubMed
  38. J Nucl Med. 2004 Jul;45(7):1251-9 - PubMed
  39. J Magn Reson Imaging. 2002 Oct;16(4):352-61 - PubMed
  40. Eur J Nucl Med. 2000 Jul;27(7):867-9 - PubMed
  41. Med Phys. 2006 May;33(5):1259-68 - PubMed
  42. J Nucl Med. 1991 Jun;32(6):1225-9 - PubMed
  43. Nucl Med Commun. 2006 Jul;27(7):595-6 - PubMed
  44. J Nucl Med. 2007 Jan;48(1):115-21 - PubMed
  45. Circulation. 2003 Oct 28;108(17):2127-33 - PubMed
  46. Anticancer Drugs. 2006 Jul;17(6):601-8 - PubMed
  47. Phys Med Biol. 2008 May 7;53(9):2233-52 - PubMed
  48. J Nucl Med. 2009 Apr;50(4):599-605 - PubMed
  49. Clin Cancer Res. 2005 Jun 1;11(11):4022-8 - PubMed
  50. Mol Imaging Biol. 2009 May-Jun;11(3):195-203 - PubMed
  51. Clin Nucl Med. 1995 Nov;20(11):973-5 - PubMed
  52. Ann Oncol. 2006 Dec;17(12):1733-42 - PubMed
  53. Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1136-45 - PubMed
  54. Methods. 2009 Jun;48(2):83-91 - PubMed
  55. J Nucl Med. 1998 Nov;39(11):1928-36 - PubMed
  56. Prostate Cancer Prostatic Dis. 2002;5(2):132-5 - PubMed
  57. J Nucl Med. 2005 Jun;46(6):1005-11 - PubMed
  58. Eur J Nucl Med Mol Imaging. 2007 Jun;34 Suppl 1:S27-33 - PubMed
  59. Semin Nucl Med. 1990 Jan;20(1):80-91 - PubMed
  60. Clin Nucl Med. 2003 Apr;28(4):267-76 - PubMed
  61. J Nucl Med. 2009 Apr;50(4):635-43 - PubMed
  62. Int J Pharm. 2006 Jun 19;316(1-2):162-9 - PubMed
  63. Nucl Med Commun. 2003 Nov;24(11):1149-54 - PubMed
  64. J Nucl Med. 1999 Jan;40(1):184-91 - PubMed
  65. Circ Res. 2000 Jun 9;86(11):1107-13 - PubMed
  66. J Nucl Med. 2002 Aug;43(8):1072-83 - PubMed
  67. Cell. 2000 Jan 7;100(1):57-70 - PubMed
  68. Q J Nucl Med Mol Imaging. 2009 Aug;53(4):374-81 - PubMed
  69. J Nucl Med. 2001 Sep;42(9):1418-23 - PubMed
  70. Eur J Nucl Med Mol Imaging. 2005 Nov;32(11):1305-10 - PubMed
  71. Eur J Nucl Med Mol Imaging. 2002 Nov;29(11):1507-15 - PubMed
  72. Eur J Nucl Med Mol Imaging. 2009 Mar;36 Suppl 1:S3-9 - PubMed
  73. Cancer. 1993 Dec 1;72(11 Suppl):3453-62 - PubMed
  74. J Clin Oncol. 1996 Aug;14(8):2295-305 - PubMed
  75. Semin Nucl Med. 2001 Oct;31(4):321-9 - PubMed
  76. J Nucl Med. 2006 May;47(5):877-84 - PubMed
  77. Methods. 2010 Jan;50(1):2-13 - PubMed
  78. Circulation. 2003 Dec 23;108(25):3134-9 - PubMed
  79. Chest. 2004 Feb;125(2):494-501 - PubMed
  80. Cell Res. 2009 Mar;19(3):370-9 - PubMed
  81. Eur J Nucl Med Mol Imaging. 2005 Aug;32(8):925-31 - PubMed
  82. Nucl Med Commun. 1994 Sep;15(9):718-22 - PubMed

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