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Popalzai MJ, Aoun N, Baz W, et al. A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia. Clin Med Insights Oncol. 2011;5:83-7doi: 10.4137/CMO.S5733.
Popalzai, M. J., Aoun, N., Baz, W., Mourad, M., Forte, F., & Friscia, P. (2011). A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia. Clinical Medicine Insights. Oncology, 583-7. https://doi.org/10.4137/CMO.S5733
Popalzai, Muhammad J, et al. "A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia." Clinical Medicine Insights. Oncology vol. 5 (2011): 83-7. doi: https://doi.org/10.4137/CMO.S5733
Popalzai MJ, Aoun N, Baz W, Mourad M, Forte F, Friscia P. A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia. Clin Med Insights Oncol. 2011;5:83-7. doi: 10.4137/CMO.S5733. Epub 2011 Apr 17. PMID: 21603243; PMCID: PMC3095024.
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Clin Med Insights Oncol. 2011;5:83-7. doi: 10.4137/CMO.S5733. Epub 2011 Apr 17.

A case of metastatic mucoepidermoid carcinoma complicated by resistant hypercalcemia.

Clinical Medicine Insights. Oncology

Muhammad J Popalzai, Nelly Aoun, Walid Baz, Mervat Mourad, Frank Forte, Philip Friscia

Affiliations

  1. Department of Hematology/Oncology, Staten Island University Hospital, Staten Island, NY, 10305, USA.

PMID: 21603243 PMCID: PMC3095024 DOI: 10.4137/CMO.S5733

Abstract

Tumors of salivary glands are uncommon and comprise of about 2%-4% of all head and neck tumors. About 75%-80% of these tumors are benign and include pleomorphic adenoma, monomorphic adenoma, oncocytoma, and papillary cystadenoma lymphomatosum. Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands, representing 5-10% of all salivary gland tumors. Although known to be metastatic to local lymph nodes, distant metastases are rare (especially, with low and intermediate grade tumors). Histologic grade and the expression of various mucin glycoproteins are useful prognostic indicators. We present a case of mucoepidermoid carcinoma of parotid gland origin with distant metastases which is an uncommon occurrence with intermediate grade tumors. Also, this is the first reported case of humoral hypercalcemia of malignancy secondary to mucoepidermoid carcinoma.

Keywords: humoral hypercalcemia of malignancy; mucoepidermoid carcinoma; salivary gland tumors

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