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Christiansen N, Christiansen H, Berthold F, et al. Transcriptional activity of N-myc and ngf-R in 50 primary human neuroblastomas as predictor for clinical outcome. Int J Oncol. 1993;3(5):853-7doi: 10.3892/ijo.3.5.853.
Christiansen, N., Christiansen, H., Berthold, F., & Lampert, F. (1993). Transcriptional activity of N-myc and ngf-R in 50 primary human neuroblastomas as predictor for clinical outcome. International journal of oncology, 3(5), 853-7. https://doi.org/10.3892/ijo.3.5.853
Christiansen, N, et al. "Transcriptional activity of N-myc and ngf-R in 50 primary human neuroblastomas as predictor for clinical outcome." International journal of oncology vol. 3,5 (1993): 853-7. doi: https://doi.org/10.3892/ijo.3.5.853
Christiansen N, Christiansen H, Berthold F, Lampert F. Transcriptional activity of N-myc and ngf-R in 50 primary human neuroblastomas as predictor for clinical outcome. Int J Oncol. 1993 Nov;3(5):853-7. doi: 10.3892/ijo.3.5.853. PMID: 21573443.
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Int J Oncol. 1993 Nov;3(5):853-7. doi: 10.3892/ijo.3.5.853.

Transcriptional activity of N-myc and ngf-R in 50 primary human neuroblastomas as predictor for clinical outcome.

International journal of oncology

N Christiansen, H Christiansen, F Berthold, F Lampert

Affiliations

  1. UNIV GIESSEN,KINDERKLIN,FEULGENSTR 12,D-35385 GIESSEN,GERMANY. UNIV COLOGNE,KINDERKLIN,D-50931 COLOGNE,GERMANY.

PMID: 21573443 DOI: 10.3892/ijo.3.5.853

Abstract

N-myc oncogene amplification in human neuroblastoma predicts an unfavourable prognosis for the patients. Even for patients with a single copy of N-myc the survival probability is only about 70%. To specify the prognosis of patients with N-myc non-amplified neuroblastoma we performed RNA expression analyses of genes related to neural differentiation in 50 primary neuroblastomas, i.e. examined the proto-oncogene N-myc and ngf-r, the gene for the nerve growth factor receptor (NGF-r), in the same tumor tissue. We found that patients with high levels of ngf-r expression, seen in 67% of stage I, II and IVs and in 59% of stage III and IV tumors, had a probability of survival of 100% in the presence of no or low levels of N-myc expression and a non-amplified N-myc in all cases. Low ngf-r expression levels were seen in 31% of stage III and IV tumors in comparison to only 5% in stage I, II, and IVs, accompanied by low, medium or high N-myc transcriptional activity and a non-amplified N-myc in 30%, and this indicates a probability of survival of only approximately 50%. Tumors characterized by medium expression levels of ngf-r and N-myc have a probability of survival of about 80%. In conclusion, RNA expression measurements, as performed for ngf-r and N-myc, can delineate prognostic subgroups within defined clinical stages and N-myc non-amplified tumors and thus, be utilized as prognostic indicators in human neuroblastoma.

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