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Caulin C, Gandarillas A, Scholl F, et al. Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture. Int J Oncol. 1993;2(3):373-9doi: 10.3892/ijo.2.3.373.
Caulin, C., Gandarillas, A., Scholl, F., & Quintanilla, M. (1993). Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture. International journal of oncology, 2(3), 373-9. https://doi.org/10.3892/ijo.2.3.373
Caulin, C, et al. "Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture." International journal of oncology vol. 2,3 (1993): 373-9. doi: https://doi.org/10.3892/ijo.2.3.373
Caulin C, Gandarillas A, Scholl F, Quintanilla M. Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture. Int J Oncol. 1993 Mar;2(3):373-9. doi: 10.3892/ijo.2.3.373. PMID: 21573564.
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Int J Oncol. 1993 Mar;2(3):373-9. doi: 10.3892/ijo.2.3.373.

Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.

International journal of oncology

C Caulin, A Gandarillas, F Scholl, M Quintanilla

Affiliations

  1. CSIC,INST INVEST BIOMED,ARTURO DUPERIER 4,E-28029 MADRID,SPAIN.

PMID: 21573564 DOI: 10.3892/ijo.2.3.373

Abstract

The aberrant expression of embryonic simple epithelial keratins K8 and K18 has been previously detected in chemically-induced mouse skin carcinomas and in cultured epidermal keratinocytes containing H-ras oncogenes. In this study, we report that cell lines derived from benign papillomas do not generally synthesize simple epithelial keratins, regardless of the presence of H-ras gene alterations. These results reinforce our previous suggestion that the expression of these keratins during mouse epidermal carcinogenesis is a marker of malignant transformation. The comparison of the two-dimensional electrophoresis intermediate filament protein profiles of transformed keratinocytes in culture, reveal that during in vitro progression to the malignant phenotype increased synthesis of simple epithelial keratins is associated to a general disturbance on the expression of cytoskeletal proteins.

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