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Kruczynski A, Jannot M, Astruc J, et al. The use of nuclear-DNA content to monitor the chemosensitivity of human non-small-cell-lung (nsclc) and colorectal cancers xenografted onto nude-mice. Int J Oncol. 1993;2(4):593-9doi: 10.3892/ijo.2.4.593.
Kruczynski, A., Jannot, M., Astruc, J., Chazottes, E., Limouzy, A., & Kiss, R. (1993). The use of nuclear-DNA content to monitor the chemosensitivity of human non-small-cell-lung (nsclc) and colorectal cancers xenografted onto nude-mice. International journal of oncology, 2(4), 593-9. https://doi.org/10.3892/ijo.2.4.593
Kruczynski, A, et al. "The use of nuclear-DNA content to monitor the chemosensitivity of human non-small-cell-lung (nsclc) and colorectal cancers xenografted onto nude-mice." International journal of oncology vol. 2,4 (1993): 593-9. doi: https://doi.org/10.3892/ijo.2.4.593
Kruczynski A, Jannot M, Astruc J, Chazottes E, Limouzy A, Kiss R. The use of nuclear-DNA content to monitor the chemosensitivity of human non-small-cell-lung (nsclc) and colorectal cancers xenografted onto nude-mice. Int J Oncol. 1993 Apr;2(4):593-9. doi: 10.3892/ijo.2.4.593. PMID: 21573597.
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Int J Oncol. 1993 Apr;2(4):593-9. doi: 10.3892/ijo.2.4.593.

The use of nuclear-DNA content to monitor the chemosensitivity of human non-small-cell-lung (nsclc) and colorectal cancers xenografted onto nude-mice.

International journal of oncology

A Kruczynski, M Jannot, J Astruc, E Chazottes, A Limouzy, R Kiss

Affiliations

  1. CTR RECH PIERRE FABRE,DIV CANCEROL EXPTL 1,17 AVE JEAN MOULIN,F-81106 CASTRES,FRANCE. UNIV LIBRE BRUXELLES,FAC MED,HISTOL LAB,B-1070 BRUSSELS,BELGIUM. FONDS NATL RECH SCI,B-1050 BRUSSELS,BELGIUM.

PMID: 21573597 DOI: 10.3892/ijo.2.4.593

Abstract

The chemosensitivity of human lung and colorectal tumours grafted onto nude mice was assessed at the individual tumour-bearing mouse level. The results show that various pieces of a given tumour grafted onto a number of animals exhibit different profiles of sensitivity to the same chemotherapy. We used the nuclear DNA content to subtype the clonal tumour heterogeneity of these models. This monitoring was performed by means of the digital cell image analysis of Feulgen-stained nuclei. The data show that the nuclear DNA content of human lung and colorectal models vanes markedly not only over serial transplantations onto animals on the one hand, but also within one and the same xenografted tumour during its spontaneous growth on the other. Such nuclear DNA content variations might explain the variability of the chemosensitivity within a given human xenograft model.

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