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Hartmann K, Teckentrup R, Nixdorf D, et al. Influence of insulin-like growth factor-I antiserum to proliferation of T-cell receptor-activated human T-lymphocytes. Int J Oncol. 1993;2(6):1003-8doi: 10.3892/ijo.2.6.1003.
Hartmann, K., Teckentrup, R., Nixdorf, D., Meuer, S., Papa, V., & Heinrich, U. (1993). Influence of insulin-like growth factor-I antiserum to proliferation of T-cell receptor-activated human T-lymphocytes. International journal of oncology, 2(6), 1003-8. https://doi.org/10.3892/ijo.2.6.1003
Hartmann, K, et al. "Influence of insulin-like growth factor-I antiserum to proliferation of T-cell receptor-activated human T-lymphocytes." International journal of oncology vol. 2,6 (1993): 1003-8. doi: https://doi.org/10.3892/ijo.2.6.1003
Hartmann K, Teckentrup R, Nixdorf D, Meuer S, Papa V, Heinrich U. Influence of insulin-like growth factor-I antiserum to proliferation of T-cell receptor-activated human T-lymphocytes. Int J Oncol. 1993 Jun;2(6):1003-8. doi: 10.3892/ijo.2.6.1003. PMID: 21573660.
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Int J Oncol. 1993 Jun;2(6):1003-8. doi: 10.3892/ijo.2.6.1003.

Influence of insulin-like growth factor-I antiserum to proliferation of T-cell receptor-activated human T-lymphocytes.

International journal of oncology

K Hartmann, R Teckentrup, D Nixdorf, S Meuer, V Papa, U Heinrich

Affiliations

  1. DEPT PEDIAT,FRANKFURT,GERMANY. UNIV CATANIA,DEPT ENDOCRINOL,I-95124 CATANIA,ITALY. UNIV HEIDELBERG,DEPT PEDIAT ENDOCRINOL,W-6900 HEIDELBERG,GERMANY. UNIV HEIDELBERG,CANC RES CTR,W-6900 HEIDELBERG,GERMANY.

PMID: 21573660 DOI: 10.3892/ijo.2.6.1003

Abstract

We have previously reported that Insulin-like growth factor (IGF-I) is a cellular growth factor of human transformed T-lymphocytes. To evaluate the role of IGF-I for nontransformed T-cells we investigated synthesis of IGF-I and the influence of an IGF-I antiserum, UBK487, during proliferation process. IGF-I is synthesized by B-lymphocytes and monocytes during proliferation. Via the T-cell receptor (CD3 subunit) induced proliferation of resting T-cells was inhibited by addition of UBK487. The addition of monocytes to the resting T-cell fraction reversed the UBK487 effect. Using UBK487, a 12 kDa protein could be immunoprecipitated from unstimulated or PHA stimulated T-cells whereas a 36 kDa protein could be immunoprecipitated from OKT3 stimulated T-cells.

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