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Cazin J, Gosselin P, Boniface B, et al. Expression of ps2 and cathepsin-d in breast-cancer. Int J Oncol. 1993;2(6):1081-4doi: 10.3892/ijo.2.6.1081.
Cazin, J., Gosselin, P., Boniface, B., Boniface, M., & Demaille, A. (1993). Expression of ps2 and cathepsin-d in breast-cancer. International journal of oncology, 2(6), 1081-4. https://doi.org/10.3892/ijo.2.6.1081
Cazin, J, et al. "Expression of ps2 and cathepsin-d in breast-cancer." International journal of oncology vol. 2,6 (1993): 1081-4. doi: https://doi.org/10.3892/ijo.2.6.1081
Cazin J, Gosselin P, Boniface B, Boniface M, Demaille A. Expression of ps2 and cathepsin-d in breast-cancer. Int J Oncol. 1993 Jun;2(6):1081-4. doi: 10.3892/ijo.2.6.1081. PMID: 21573676.
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Int J Oncol. 1993 Jun;2(6):1081-4. doi: 10.3892/ijo.2.6.1081.

Expression of ps2 and cathepsin-d in breast-cancer.

International journal of oncology

J Cazin, P Gosselin, B Boniface, M Boniface, A Demaille

Affiliations

  1. CTR OSCAR LAMBRET,RADIOPHARM & ONCOPHARMACOL LAB,RUE F COMBEMALE,BP 307,F-59020 LILLE,FRANCE. FAC SCI PHARMACEUT & BIOL LILLE,LILLE,FRANCE.

PMID: 21573676 DOI: 10.3892/ijo.2.6.1081

Abstract

Cytosolic levels of pS2 and Cathepsin D (Cath D) were compared in 145 primary breast cancer patients using the immunoradiometric (IRMA) assays ELSA-pS2-degrees and ELSA-Cath. D-degrees of Cis biointernational. The mean values were 20.04 +/- 41.75 ng pS2/mg of cytosol protein (cp) and 49.94 +/- 33.71 pmol Cath D/mg cp. The pS2 level was significantly associated with Estrogen Receptor (ER), Progesterone Receptor (PgR) and Cath D levels. Significant associations were also found between Log (pS2) or Log (Cath. D) and differentiation grade (SBR), between Log (pS2) and ER (+,-) or PgR (+,-), between Log (Cath. D) and PgR (+,-). No correlations were noted between Log (pS2) or Log (Cath D) and menopausal status, tumor size (T) and lymph node involvement (N), between pS2 and age, between Cath D and age, ER and PgR, between Log (Cath D) and ER (+,-). Contrary to Cath D, pS2 was strongly linked to steroid receptors.

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