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Comabella M, Khoury SJ. Immunopathogenesis of multiple sclerosis. Clin Immunol. 2011;142(1):2-8doi: 10.1016/j.clim.2011.03.004.
Comabella, M., & Khoury, S. J. (2012). Immunopathogenesis of multiple sclerosis. Clinical immunology (Orlando, Fla.), 142(1), 2-8. https://doi.org/10.1016/j.clim.2011.03.004
Comabella, Manuel, and Khoury, Samia J. "Immunopathogenesis of multiple sclerosis." Clinical immunology (Orlando, Fla.) vol. 142,1 (2012): 2-8. doi: https://doi.org/10.1016/j.clim.2011.03.004
Comabella M, Khoury SJ. Immunopathogenesis of multiple sclerosis. Clin Immunol. 2012 Jan;142(1):2-8. doi: 10.1016/j.clim.2011.03.004. Epub 2011 Mar 12. PMID: 21458377.
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Clin Immunol. 2012 Jan;142(1):2-8. doi: 10.1016/j.clim.2011.03.004. Epub 2011 Mar 12.

Immunopathogenesis of multiple sclerosis.

Clinical immunology (Orlando, Fla.)

Manuel Comabella, Samia J Khoury

Affiliations

  1. Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. [email protected]

PMID: 21458377 DOI: 10.1016/j.clim.2011.03.004

Abstract

Multiple sclerosis (MS) is a chronic disorder of the central nervous system characterized by autoimmune inflammation, demyelination, and axonal damage. MS etiology remains unknown, but disease phenotype is most likely the result of an interaction between complex genetic factors and environmental influences. The better understanding of the mechanisms involved in the immunopathogenesis of MS has led to the development of promising new therapeutic strategies for the disease. This review will discuss the key pathogenic steps implicated in the disease and the role of the main cellular populations that drive the immune responses in MS.

Copyright © 2011 Elsevier Inc. All rights reserved.

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