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Caraglia M, Leardi A, Ricciardi B, et al. alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. Int J Oncol. 1996;8(5):847-50doi: 10.3892/ijo.8.5.847.
Caraglia, M., Leardi, A., Ricciardi, B., Delaurentiis, M., Graziano, M., Matano, E., Deplacido, S., Bianco, A., & Tagliaferri, P. (1996). alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. International journal of oncology, 8(5), 847-50. https://doi.org/10.3892/ijo.8.5.847
Caraglia, M, et al. "alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies." International journal of oncology vol. 8,5 (1996): 847-50. doi: https://doi.org/10.3892/ijo.8.5.847
Caraglia M, Leardi A, Ricciardi B, Delaurentiis M, Graziano M, Matano E, Deplacido S, Bianco A, Tagliaferri P. alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. Int J Oncol. 1996 May;8(5):847-50. doi: 10.3892/ijo.8.5.847. PMID: 21544436.
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Int J Oncol. 1996 May;8(5):847-50. doi: 10.3892/ijo.8.5.847.

alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies.

International journal of oncology

M Caraglia, A Leardi, B Ricciardi, M Delaurentiis, M Graziano, E Matano, S Deplacido, A Bianco, P Tagliaferri

Affiliations

  1. UNIV NAPLES FEDERICO II,FAC MED,DIPARTIMENTO ENDOCRINOL & ONCOL MOL & CLIN,CATTEDRA ONCOL MED,I-80131 NAPLES,ITALY.

PMID: 21544436 DOI: 10.3892/ijo.8.5.847

Abstract

We have demonstrated that interferon-alpha 2 recombinant (IFN alpha) inhibits the growth and modulates the expression of the receptor for transferrin (TRF-R) in human epidermoid carcinoma KB cells. Receptor upregulation results in the reconstitution of intracellular iron levels in the IFN alpha-treated cells. Several anti-TRF-R murine monoclonal antibodies (MAbs) have been generated which induce tumor cell growth inhibition through blockade of receptor function. We have evaluated by MTT assay the effect of anti-TRF-R 42/6, E2.3, A27.15 and D65.30 MAbs given in combination with IFN alpha on the growth of human epidermoid carcinoma KB cells. We found that IFN alpha and A27.15 MAb induced a synergistic antiproliferative effect on these cells. These results suggest that IFN alpha may potentiate the antitumor efficacy of TRF-R-targeted therapy.

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