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Joffe YT, van der Merwe L, Collins M, et al. The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women. Genes Nutr. 2011;6(4):353-9doi: 10.1007/s12263-011-0213-2.
Joffe, Y. T., van der Merwe, L., Collins, M., Carstens, M., Evans, J., Lambert, E. V., & Goedecke, J. H. (2011). The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women. Genes & nutrition, 6(4), 353-9. https://doi.org/10.1007/s12263-011-0213-2
Joffe, Yael T, et al. "The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women." Genes & nutrition vol. 6,4 (2011): 353-9. doi: https://doi.org/10.1007/s12263-011-0213-2
Joffe YT, van der Merwe L, Collins M, Carstens M, Evans J, Lambert EV, Goedecke JH. The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women. Genes Nutr. 2011 Nov;6(4):353-9. doi: 10.1007/s12263-011-0213-2. Epub 2011 Mar 08. PMID: 21484162; PMCID: PMC3197842.
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Genes Nutr. 2011 Nov;6(4):353-9. doi: 10.1007/s12263-011-0213-2. Epub 2011 Mar 08.

The -308 G/A polymorphism of the tumour necrosis factor-α gene modifies the association between saturated fat intake and serum total cholesterol levels in white South African women.

Genes & nutrition

Yael T Joffe, Lize van der Merwe, Malcolm Collins, Madelaine Carstens, Juliet Evans, Estelle V Lambert, Julia H Goedecke

Affiliations

  1. UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Newlands, Cape Town, South Africa.

PMID: 21484162 PMCID: PMC3197842 DOI: 10.1007/s12263-011-0213-2

Abstract

This study explored interactions between dietary fat intake and the tumour necrosis factor-α gene (TNFA) -308 G/A polymorphism on serum lipids in white South African (SA) women. Normal-weight (N = 88) and obese (N = 60) white SA women underwent measurements of body composition, fat distribution, fasting serum lipids, glucose, insulin concentrations and dietary intake. Subjects were genotyped for the functional -308 G/A polymorphism within the TNFA gene. There were no significant differences in the genotype or allele frequencies between groups, and no significant genotype associations were found for body fatness or distribution, or serum lipid concentrations. However, there was a significant interaction effect between dietary saturated fat (SFA) intake (%E) and TNFA -308 genotypes on serum total cholesterol concentrations (P = 0.047). With increasing SFA intake (%E), serum total cholesterol levels decreased for the GG genotype and increased for the GA plus AA genotypes. The TNFA -308 G/A polymorphism appears to modify the relationship between dietary fat intake and serum total cholesterol concentrations in white SA women.

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