Display options
Cite
Ierardi E, Rosania R, Zotti M, et al. Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries. World J Gastrointest Pathophysiol. 2010;1(3):91-6doi: 10.4291/wjgp.v1.i3.91.
Ierardi, E., Rosania, R., Zotti, M., Principe, S., Laonigro, G., Giorgio, F., de Francesco, V., & Panella, C. (2010). Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries. World journal of gastrointestinal pathophysiology, 1(3), 91-6. https://doi.org/10.4291/wjgp.v1.i3.91
Ierardi, Enzo, et al. "Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries." World journal of gastrointestinal pathophysiology vol. 1,3 (2010): 91-6. doi: https://doi.org/10.4291/wjgp.v1.i3.91
Ierardi E, Rosania R, Zotti M, Principe S, Laonigro G, Giorgio F, de Francesco V, Panella C. Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries. World J Gastrointest Pathophysiol. 2010 Aug 15;1(3):91-6. doi: 10.4291/wjgp.v1.i3.91. PMID: 21607146; PMCID: PMC3097951.
Copy Download .nbib Format: NLM
Share it on

World J Gastrointest Pathophysiol. 2010 Aug 15;1(3):91-6. doi: 10.4291/wjgp.v1.i3.91.

Metabolic syndrome and gastro-esophageal reflux: A link towards a growing interest in developed countries.

World journal of gastrointestinal pathophysiology

Enzo Ierardi, Rosa Rosania, Mariangela Zotti, Simonetta Principe, Giulio Laonigro, Floriana Giorgio, Vincenzo de Francesco, Carmine Panella

Affiliations

  1. Enzo Ierardi, Rosa Rosania, Mariangela Zotti, Simonetta Principe, Giulio Laonigro, Floriana Giorgio, Vincenzo de Francesco, Carmine Panella, Gastroenterology Section, Department of Medical Sciences, University of Foggia, Foggia 71100, Italy.

PMID: 21607146 PMCID: PMC3097951 DOI: 10.4291/wjgp.v1.i3.91

Abstract

The aim of this Editorial is to describe the growing possibility of a link between gastro-esophageal reflux disease (GERD) and metabolic syndrome on the light of recent epidemiological and pathophysiological evidence. The state of the art of GERD is described, based on recent definitions, pathophysiological evidence, epidemiology in developed countries, clinical subtypes together with a diagnostic approach specifically focussed on the appropriateness of endoscopy. Metabolic syndrome is accurately defined and the pivotal role of insulin resistance is emphasized. The strong relationship between GERD and metabolic syndrome has been pathophysiologically analyzed, taking into account the role of obesity, mechanical factors and metabolic changes. Data collected by our group regarding eating habits and GERD are briefly summarized at the end of a pathophysiological analysis. The literature on the subject strongly supports the possibility that lifestyle and eating habits may be involved in both GERD and metabolic syndrome in developed countries.

Keywords: Gastroesophageal reflux disease; Insulin resistance; Metabolic syndrome; Obesity

References

  1. Baillieres Best Pract Res Clin Gastroenterol. 2000 Oct;14(5):743-57 - PubMed
  2. Ann Surg. 1976 Oct;184(4):459-70 - PubMed
  3. Lancet. 2005 Sep 24-30;366(9491):1059-62 - PubMed
  4. Neurogastroenterol Motil. 2006 Jun;18(6):425-32 - PubMed
  5. Gastroenterology. 2008 May;134(5):1620-2 - PubMed
  6. J Clin Gastroenterol. 2007 Jul;41(6):539-45 - PubMed
  7. Gut. 2009 Feb;58(2):174-81 - PubMed
  8. Gut. 2005 May;54(5):710-7 - PubMed
  9. Obes Surg. 2004 Jun-Jul;14(6):744-9 - PubMed
  10. Surg Endosc. 2007 May;21(5):761-4 - PubMed
  11. Gastroenterology. 2006 Mar;130(3):639-49 - PubMed
  12. J Gastroenterol. 2006 May;41(5):509-10 - PubMed
  13. Am J Gastroenterol. 2006 Aug;101(8):1900-20; quiz 1943 - PubMed
  14. Lancet. 2006 Jun 24;367(9528):2086-100 - PubMed
  15. Lipids Health Dis. 2010 Apr 28;9:42 - PubMed
  16. Science. 2003 Feb 7;299(5608):781 - PubMed
  17. Gastroenterology. 1972 Nov;63(5):778-83 - PubMed
  18. Med Sci Sports Exerc. 2003 Oct;35(10):1703-9 - PubMed
  19. Cardiol Rev. 2005 Nov-Dec;13(6):322-7 - PubMed
  20. Dtsch Med Wochenschr. 2009 Sep;134(37):1812-6 - PubMed
  21. Aliment Pharmacol Ther. 2006 Mar 15;23(6):751-7 - PubMed
  22. Obes Surg. 1999 Aug;9(4):390-5 - PubMed
  23. Ann Surg. 2008 Jun;247(6):909-15 - PubMed
  24. Obes Surg. 2007 Jul;17(7):894-900 - PubMed
  25. Gut. 1999 Aug;45(2):172-80 - PubMed
  26. JAMA. 2006 Apr 5;295(13):1549-55 - PubMed
  27. Obes Surg. 2005 Oct;15(9):1225-32 - PubMed
  28. Aliment Pharmacol Ther. 2006 Jan 1;23(1):169-74 - PubMed
  29. Am J Dig Dis. 1976 Nov;21(11):953-6 - PubMed
  30. Am J Surg. 1996 Jan;171(1):182-6 - PubMed
  31. J Gastroenterol Hepatol. 2008 Jan;23(1):8-22 - PubMed
  32. Am J Gastroenterol. 1988 Jun;83(6):633-6 - PubMed
  33. Scand J Gastroenterol. 2006 Aug;41(8):887-91 - PubMed
  34. Oncogene. 2002 Sep 5;21(39):6071-81 - PubMed
  35. N Engl J Med. 2006 Jun 1;354(22):2340-8 - PubMed
  36. Surg Endosc. 2002 Nov;16(11):1631-5 - PubMed
  37. CNS Spectr. 2001 Jul;6(7):581-6, 589 - PubMed
  38. Gastrointest Endosc. 2007 Aug;66(2):219-24 - PubMed
  39. Arch Surg. 2005 Jul;140(7):639-43 - PubMed
  40. Gastrointest Endosc Clin N Am. 2000 Apr;10(2):265-73 - PubMed
  41. Gut. 2008 Mar;57(3):281-4 - PubMed
  42. South Med J. 1985 Apr;78(4):452-7 - PubMed
  43. Gastroenterology. 2006 Aug;131(2):390-401; quiz 659-60 - PubMed
  44. Lancet. 2005 Apr 16-22;365(9468):1415-28 - PubMed
  45. Diabetes. 1988 Dec;37(12):1595-607 - PubMed
  46. Gastrointest Endosc. 1999 Jun;49(6):834-5 - PubMed
  47. Am J Gastroenterol. 2008 Jun;103(6):1349-54 - PubMed

Publication Types