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Fushida S, Yonemura Y, Urano T, et al. Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant. Oncol Rep. 1994;1(1):111-5doi: 10.3892/or.1.1.111.
Fushida, S., Yonemura, Y., Urano, T., Tsugawa, K., Miyazaki, I., & Shiku, H. (1994). Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant. Oncology reports, 1(1), 111-5. https://doi.org/10.3892/or.1.1.111
Fushida, S, et al. "Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant." Oncology reports vol. 1,1 (1994): 111-5. doi: https://doi.org/10.3892/or.1.1.111
Fushida S, Yonemura Y, Urano T, Tsugawa K, Miyazaki I, Shiku H. Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant. Oncol Rep. 1994 Jan;1(1):111-5. doi: 10.3892/or.1.1.111. PMID: 21607317.
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Oncol Rep. 1994 Jan;1(1):111-5. doi: 10.3892/or.1.1.111.

Higher frequency of ras oncogene activation in gastric stump carcinomas due to special conditions in the gastric remnant.

Oncology reports

S Fushida, Y Yonemura, T Urano, K Tsugawa, I Miyazaki, H Shiku

Affiliations

  1. KANAZAWA UNIV,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN. NAGASAKI UNIV,SCH MED,DEPT ONCOL,NAGASAKI 852,JAPAN.

PMID: 21607317 DOI: 10.3892/or.1.1.111

Abstract

Gastric stump carcinoma is now widely recognized to be due to special conditions in the gastric remnant. To examine whether the mechanism of carcinogenesis is different in gastric stump carcinoma from other gastric carcinoma, we analyzed ras mutation in 62 gastric carcinomas. The ras mutation frequency was 4/17 (23.5%) in stump carcinomas, 2/25 (8.0%) in other remnant carcinomas and 1/20 (5.0%) in proximal carcinomas. The mutation frequency in stump carcinomas was much higher than that in other gastric carcinomas. These results suggest that the mechanism of carcinogenesis in gastric stump carcinomas may be different from other gastric carcinomas.

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