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Koutselini H, Malliri A, Papadakis E, et al. C-jun oncogene expression in nonsmall cell lung-cancer. Oncol Rep. 1994;1(2):353-6
Koutselini, H., Malliri, A., Papadakis, E., Gillespie, D., & Spandidos, D. (1994). C-jun oncogene expression in nonsmall cell lung-cancer. Oncology reports, 1(2), 353-6.
Koutselini, H, et al. "C-jun oncogene expression in nonsmall cell lung-cancer." Oncology reports vol. 1,2 (1994): 353-6.
Koutselini H, Malliri A, Papadakis E, Gillespie D, Spandidos D. C-jun oncogene expression in nonsmall cell lung-cancer. Oncol Rep. 1994 Mar;1(2):353-6. PMID: 21607364.
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Oncol Rep. 1994 Mar;1(2):353-6.

C-jun oncogene expression in nonsmall cell lung-cancer.

Oncology reports

H Koutselini, A Malliri, E Papadakis, D Gillespie, D Spandidos

Affiliations

  1. NATL HELLEN RES FDN,INST BIOL RES & BIOTECHNOL,ATHENS,GREECE. UNIV CRETE,SCH MED,CRETE,GREECE. METAXA ANTICANC HOSP,PIRAEUS,GREECE. BEATSON INST CANC RES,GLASGOW,LANARK,SCOTLAND.

PMID: 21607364

Abstract

Primary lung cancer specimens of the non-small cell (NSC) types were examined for expression of the c-jun gene at the protein level by immunocytochemistry using the polyclonal antibody c-jun 890. The results obtained revealed that the c-jun p39 protein was expressed in 82% (18/22) of squamous cell carcinomas, 77% (10/15) of adenocarcinomas and 40% (2/5) of large cell anaplastic carcinomas, but no staining was seen in the non-cancer cases. Positive immunostaining was also seen in 16.7% (3/18) of the nonneoplastic bronchial cells of positively stained squamous cell carcinomas and in 40% (4/10) of adenocarcinomas. We suggest that elevated expression df c-jun p39 protein which was seen in a total of 75% (30/40) of the NSCLC, plays a role in lung cancer.

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