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Zeller W, Schafer B, Benz A, et al. Expression of NK-associated surface-antigens cd-56 and cd-16 on aml-cells. Oncol Rep. 1994;1(2):411-4doi: 10.3892/or.1.2.411.
Zeller, W., Schafer, B., Benz, A., Gutensohn, K., Becker, K., Fiedler, W., & Hossfeld, D. (1994). Expression of NK-associated surface-antigens cd-56 and cd-16 on aml-cells. Oncology reports, 1(2), 411-4. https://doi.org/10.3892/or.1.2.411
Zeller, W, et al. "Expression of NK-associated surface-antigens cd-56 and cd-16 on aml-cells." Oncology reports vol. 1,2 (1994): 411-4. doi: https://doi.org/10.3892/or.1.2.411
Zeller W, Schafer B, Benz A, Gutensohn K, Becker K, Fiedler W, Hossfeld D. Expression of NK-associated surface-antigens cd-56 and cd-16 on aml-cells. Oncol Rep. 1994 Mar;1(2):411-4. doi: 10.3892/or.1.2.411. PMID: 21607375.
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Oncol Rep. 1994 Mar;1(2):411-4. doi: 10.3892/or.1.2.411.

Expression of NK-associated surface-antigens cd-56 and cd-16 on aml-cells.

Oncology reports

W Zeller, B Schafer, A Benz, K Gutensohn, K Becker, W Fiedler, D Hossfeld

PMID: 21607375 DOI: 10.3892/or.1.2.411

Abstract

Monoclonal antibodies Leu 11a (CD16) and Leu 19 (CD56) were tested for reactivity with cells from 36 patients with acute myelogenous leukemia (AML) using two-colour flow cytometry. Blast cells were identified by a broad panel of monoclonal antibodies. In 33% (12/36) the monoclonal antibody Leu 19, which has been demonstrated to bind to the 140 kD isoform of the human neural cellular adhesion molecule N-CAM, found on peripheral natural killer (NK)-cells, neuroectodermal cells, activated T-cells, and myeloma cells, was shown to bind strongly to the leukemic cells. The monoclonal antibody Leu 11a, which recognizes a surface differentiation antigen associated with the low affinity FcRIII for IgG, expressed on NK-cells, granulocytes and macrophages were found to bind to leukemic cells of four of the 12 Leu-19 positive cases. 50% (6/12) of Leu-19 positive patients were classified as having M4 according to the French-American-British (FAB) morphology criteria. The potential diagnostic and clinical importance of CD 56 and/or CD 16 expression in acute myelogenous leukemia is presently under investigation.

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